ID   A0A2U1B1Y4_9BACT        Unreviewed;       877 AA.
AC   A0A2U1B1Y4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Topoisomerase-4 subunit A {ECO:0000313|EMBL:PVY42704.1};
GN   ORFNames=C8D82_11010 {ECO:0000313|EMBL:PVY42704.1};
OS   Victivallis vadensis.
OC   Bacteria; Lentisphaerota; Lentisphaeria; Victivallales; Victivallaceae;
OC   Victivallis.
OX   NCBI_TaxID=172901 {ECO:0000313|EMBL:PVY42704.1, ECO:0000313|Proteomes:UP000245959};
RN   [1] {ECO:0000313|EMBL:PVY42704.1, ECO:0000313|Proteomes:UP000245959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14823 {ECO:0000313|EMBL:PVY42704.1,
RC   ECO:0000313|Proteomes:UP000245959};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVY42704.1}.
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DR   EMBL; QEKH01000010; PVY42704.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1B1Y4; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000245959; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PVY42704.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245959};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          48..477
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          687..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..714
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..743
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        789..810
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   877 AA;  98011 MW;  9BF8E326AD06BEEA CRC64;
     MSDEPEKNEL DAPVPLDAEV VSENDDTAEN GDPNSVAAER YRGNNDYFRT MMDRNFLEYA
     SYVIKDRAIP DVDDGLKPVQ RRVLWALYQV YDGRTHKVAN VVGNTMHYHP HGNASIEDAL
     VVLANKEYYI TRQGNFGNIL TGSPAAAGRY IECSLSPLGH EVLFNNDITE FVDTYDGRGV
     EPVTLPAKVP SLLMLGSDGI AVGMATKIMP HNFNELLEAE IAVLRGEEFE LYPDFQQGGL
     MDVREYNDGN GKITLRAKIE IVGRDLIIRE IPATTSTETL VASIEKAAEK NKIKISSVND
     YTTDKVEIKV VPTRGYDPEK TMQGLYMYTD CSVSISVNMT VIRENRPVQM SVSEVLRRNA
     DKLLEYLKRE LEIDLAKQED LFHAKTLAQI FFENRIYKKI EECKSEKEEY TEVHAGLAPF
     RHLLRRDVTD QDIDKLLALP VRRISRFDIE KNQRELAEVL AKMEEIKKNL GSLKKYAINY
     LRKLLDKYGK DFPRRTEIEH FEKIDRREAA LNNIKVGWDR KNGYVGTSIK SDDILACNEF
     DRFLCVEKSG SYKVIALPPE KLFIGKLYDF RKYDAATEFG VIYRETKSGK YYGKRTAIGG
     FILDKEYNLC PVGCKLELLT PRADAVYMLT VAGARGKQQQ TELNLMELPA RSPKARGILI
     SSKPIVKITH NRYLTPEELA ALSLKTESDD EITDENDESA NGGGNGNAGT ASGETAAVPQ
     AAEPVDPPEL SEPVKKIEKP ASEVTAKITE TVEKSAQAPS KKVPEVTEDA PPWDTADGAT
     VVMEKEVAAP EPAKPKKKAG EAKPHSELPP PEVHPVDFGV EQPPNFDEPL VLTADPEPPR
     KPRHKPAAPS VPKEPRIQVP PPDGDDEFGI VQPEFGF
//