ID A0A2U1BAY1_9BACT Unreviewed; 641 AA.
AC A0A2U1BAY1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=C8D82_1014 {ECO:0000313|EMBL:PVY45815.1};
OS Victivallis vadensis.
OC Bacteria; Lentisphaerota; Lentisphaeria; Victivallales; Victivallaceae;
OC Victivallis.
OX NCBI_TaxID=172901 {ECO:0000313|EMBL:PVY45815.1, ECO:0000313|Proteomes:UP000245959};
RN [1] {ECO:0000313|EMBL:PVY45815.1, ECO:0000313|Proteomes:UP000245959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14823 {ECO:0000313|EMBL:PVY45815.1,
RC ECO:0000313|Proteomes:UP000245959};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVY45815.1}.
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DR EMBL; QEKH01000001; PVY45815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1BAY1; -.
DR OrthoDB; 9815272at2; -.
DR Proteomes; UP000245959; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR041657; HTH_17.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF12728; HTH_17; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000245959};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..50
FT /note="Helix-turn-helix"
FT /evidence="ECO:0000259|Pfam:PF12728"
FT DOMAIN 193..378
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 479..591
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 641 AA; 71762 MW; D2D6EB7FB3B56B08 CRC64;
MDALLSVREA AEFLGVSQAT VYHWARSGIL QGYQQAVRRF PAEQVHKLQR AIAAGHVPRL
NARANKRHAD GYRTPFPSRP EDGNDASQII RLRRLIRERQ LNPACILYVR ALRLLAEAGE
WEPATPFSPA LPPASRWRRQ SVARIMRGWR RDLGVSVLSA ADYRRPFELP VEPVSGSDQL
GFLYQALRRT GSRVQAGSFY TPPEVVRSMT AGLTPHDGFT LLDPGCGSGQ FLLGAAEAGW
EFDQLFGIDL DPLALRLAAL NLLLAFPAVD ALPNLKCADA LLTDSFGRRR FDVVIGNPPW
GRLADGELRR RLNRRYLRKR NFSESFSYFL LRARALAVPG GTIRFLLPEA ILNIRRHAEI
RSELLNECTW RGIAECGRKF SGVFTGAITL DLLNIPPSPN HRIEIRPEAG PEFQLLQTSL
KPESGLVIQS GPLENSIWEK VSRYPHRTLK DSGAEWALGI VTGNNRKWLL PVGSRGGEPI
VRGVEVQPYR LAPAQYEIFF DPKKFQQCAP ERLYRVPEKL VYRFISRRLV FALDRKGVLT
LNSANNLIVP PAFYPMKLIA VLFNSGLYQL LFRSRFNTHK VLRSDLEQLP LPDFPAPVRA
ELSGLADRLL AGDASAISRV DVVLASVLGL TEAEKVLVTE L
//
