ID   A0A2U1C6Y3_9BURK        Unreviewed;       881 AA.
AC   A0A2U1C6Y3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:PVY56591.1};
GN   ORFNames=C8D04_1850 {ECO:0000313|EMBL:PVY56591.1};
OS   Simplicispira sp. 125.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Simplicispira.
OX   NCBI_TaxID=2135643 {ECO:0000313|EMBL:PVY56591.1, ECO:0000313|Proteomes:UP000245599};
RN   [1] {ECO:0000313|EMBL:PVY56591.1, ECO:0000313|Proteomes:UP000245599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=125 {ECO:0000313|EMBL:PVY56591.1,
RC   ECO:0000313|Proteomes:UP000245599};
RA   Chistoserdova L.;
RT   "Synthetic bacterial communities of pure cultures isolated from sediment of
RT   Lake Washington, USA.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PVY56591.1}.
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DR   EMBL; QEKM01000001; PVY56591.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1C6Y3; -.
DR   OrthoDB; 9813903at2; -.
DR   Proteomes; UP000245599; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   CDD; cd18773; PDC1_HK_sensor; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF12860; PAS_7; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245599};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          320..357
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          479..617
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          626..880
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   881 AA;  96717 MW;  D572F276D907BF25 CRC64;
     MAWTSSRIKI TVWALASLFL VGLLFTAGML AWTTRQTALE NRVEQVTRFV SGAEAALNNS
     FLTIDLLLSG SDDLLGLSAS MVDWVDTSVS GKLLDTVTRG NLLVSHTALL DREGRVLASS
     DAASARNAVQ LPPDFLQAAL SPSAPSLLVS APTVSFNSTQ VVLYFARPSV LANGHRLVVV
     AQVPVAKMAQ VLMQGADSAG LEVVLERSNG SVLLSIPDWG EQALLRPIQP LNTPAESATW
     GAPARLSGVP ALVVSRPLLY QNLRLSASLP EEVALEDWRA ERNAIAVVTA VFCLMVLLAA
     GAAVAFFHSV TMARQAMAHS KTMLDQALES MVSGFVLLDQ RGRVVHWNRR FAEIYPWLAG
     VMAPQLPFRK VLEKTVKYHL PQADEAKQQQ WVEQRLARQR SAAGGHEQTT PDGRHIQILE
     RSTPEGGLVI TYHDVTDLRR ATAEIETLAF YDPLTGLPNR RLLLDRLGQA SVLAQRSGQL
     GALLFLDLDQ FKALNDTMGH EVGDELLIQV AQRLRACVRV ADTVARLGGD EFVVMLNDLS
     IRTEEAAQLA QRIGEKILAS LSEPYQLQGH EHQSRASIGA TVFGGSLQTA TELLKQADIA
     MYQVKARRGN GLCFFDPRMQ VAINDRAQLE ADLHDALEKR QFAVHYQPQF TLDGRIVGAE
     VLLRWHHPQR GMVPPGQFIA VAEESDLILH IGLWVLRTAC AQMAVWQDVP QCAHLQLSVN
     VSARQFRHPD FVRQVADALQ ETGAKAHLLT LELTESLVLD NVDDAIEKMH LLRTKGVRFS
     VDDFGTGYSS LAYLTRLPLH QLKIDQSFVR NLGTRETDDV IVQTIIGMGR NLDLEVIAEG
     VETQEQKDFL ARQGCDLYQG YLLGRPVPLD AFNALIQASA A
//