ID A0A2U1E5B6_9FIRM Unreviewed; 518 AA.
AC A0A2U1E5B6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=C7381_10226 {ECO:0000313|EMBL:PVY95138.1};
OS Ezakiella coagulans.
OC Bacteria; Bacillota; Tissierellia; Ezakiella.
OX NCBI_TaxID=46507 {ECO:0000313|EMBL:PVY95138.1, ECO:0000313|Proteomes:UP000245793};
RN [1] {ECO:0000313|EMBL:PVY95138.1, ECO:0000313|Proteomes:UP000245793}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20705 {ECO:0000313|EMBL:PVY95138.1,
RC ECO:0000313|Proteomes:UP000245793};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PVY95138.1}.
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DR EMBL; QEKV01000002; PVY95138.1; -; Genomic_DNA.
DR RefSeq; WP_022620839.1; NZ_QEKV01000002.1.
DR AlphaFoldDB; A0A2U1E5B6; -.
DR Proteomes; UP000245793; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF3; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01216; thioether_bond_formation_requi; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245793};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 118..349
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 518 AA; 61153 MW; 9C6F6126F23BB7DA CRC64;
MDLITLEKEK LENKYKELCK EEYPGRLGKT FKTKYNFYYY DSGTGKVAQI NENVYKVLTK
FLESENFLDF IKLDMSEQEF CEAISEIKDA INKESILSAT KFNCLTGKTY EQIDEIIDNK
IQNVTLEVTE KCNLRCKYCI YNESHPEYRA FGHRNMDWEI AKKAVEFLKS HSQNSEERHI
GFYGGEPLIN YDLIKKTTDY ANKLFDKMTY SMTTNATLMN EEIADYIMKN KFNIIVSLDG
YKELHNKNRL FVTGEGSFEK TINGLKILLR SAEKYNNKEN ITLNMVIEGP DYENKYDKIQ
VYLNECDWLP KNINILTSSI DYGPHESIYT RPQSYEERMI LKDYYDPILS WDEKNKIRNK
DNTNEIFTDA DVDKAMMIIH KRLLSEKPVK KYGMNGCCVP GERRIYVTVD GNFKICEKVG
DIPEIGNVHK GFDEKRIKEL YFDDFIKESS KYCKDCWAIN LCTLCYVNCY DQYGTHFSYR
HNSCRSERKY LLDSLIKYHE ILEENPDVLK EFNEIEFQ
//
