ID A0A2U1KJJ3_ARTAN Unreviewed; 437 AA.
AC A0A2U1KJJ3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Peptidase C1A {ECO:0000313|EMBL:PWA36898.1};
GN ORFNames=CTI12_AA595490 {ECO:0000313|EMBL:PWA36898.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA36898.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA36898.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA36898.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA36898.1}.
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DR EMBL; PKPP01017516; PWA36898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KJJ3; -.
DR STRING; 35608.A0A2U1KJJ3; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF841; CYSTEINE PROTEASE-4; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..437
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018636608"
FT DOMAIN 49..105
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 135..329
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 437 AA; 49056 MW; 2B800B560D7D4E49 CRC64;
MAFIISSKKT SLFFLFVSVL ACSALAHEFS ILGYAPEDLT SIHKVVHLFE SWVAKHSKFY
ESLDEKLHRF EIFMDNLKHI DDTNKKVSNY WLGLNEFADM SHEEFKSKYL GLKGELAERK
ETSNEEFSYR NFVDLPKSVD WRKKGAVAPV KNQGQCGSCW AFSTVAAVEG INQIVTGNLT
ELSEQELIDC DTTVNSGCNG GLMDYAFAYI MKAGGLHKEE EYPYIMSEGT CDDKKDISEK
VTISGYHDVP RNNEDSFLKA LANQPISVAI EASGRDFQFY SGGVFDGHCG IDLDHGVAAV
GYGTTKGLDY VILLKEKTND VLENNQVDHL NFFDEKDTKH LQVPMIEGRV TPKVYGGAYP
SHESERDSTT SMGEKTYFEG NVGNNEIPES INVDLNFNYG SSDEDILDVQ QQQTVARKSK
RSTKMPLSLM IMLWIVI
//
