ID A0A2U1KJS1_ARTAN Unreviewed; 481 AA.
AC A0A2U1KJS1;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=CTI12_AA594470 {ECO:0000313|EMBL:PWA37017.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA37017.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA37017.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA37017.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA37017.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PKPP01017368; PWA37017.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KJS1; -.
DR STRING; 35608.A0A2U1KJS1; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF196; PROTEIN DETOXIFICATION; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 41..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 117..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 293..311
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 369..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 481 AA; 51924 MW; 481CD080A6912449 CRC64;
MEEQGLQTPL VVQEYGKRVG PYSKDEIVCE FKKQLYLAGP LMAVNLLVCA LSMISVMFVG
HLGELALSGA SMATSFASVT GTSLMIGMGS ALDTFCGQSY GAKEYHLLGI HMQRAMIVLL
STCIPLAFIW ANAATLLVFL GQDPEISAEA GLYAKFMIPS LFGNALLQCH VRFLQSQNNV
VPMMLSTGIT TLLHILVCWI MVFKSGLGSR GAALANALSC WLNVSLLALY VRFAPACKKT
WTGFSKEALL NIPTFLKLAV PSAVMVCLEI WSFEMMVLLS GLLPNPQLET SVLSISLNTC
SMLYMIPLGL SSATSVRVSN ELGAGRARAA LLAIRVSMFA VITEGVLGAL ILIFGRKLWG
YCYSNEEEVV SYIAQMMLLL AGGYIVDGIQ SVLSGAVRGS GRQKIGAVAN LGAYYIIGIP
LAILFAFVFH MGGKGLWFGI IAALFAQSLF LLILTLCTNW ENEAKKANQR VHDSMIQDQV
S
//
