ID A0A2U1KJV7_ARTAN Unreviewed; 1447 AA.
AC A0A2U1KJV7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=CTI12_AA594570 {ECO:0000313|EMBL:PWA37008.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA37008.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA37008.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA37008.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA37008.1}.
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DR EMBL; PKPP01017385; PWA37008.1; -; Genomic_DNA.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF515; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 2.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1447 AA; 165220 MW; 8F96A6BECCCCF498 CRC64;
MATTSIPHRW KYDVFVSFRG DDIRKSFMDH MFNDFKQKGI HVFRDDIELP KGEEISPQLS
KAIEESRFLI VIFSKNYASS SWCLRELVKI LDCKQMGKPK HEVQIIFYDV KPDVVRKQTG
SYAGAFAKHD VSNRTEVGQW KEALSMAANL SGWDLQDMTN GFESKFIDSI SREILKKLCD
GTLHVGENLV GIDIHFDKLD LSRFIGSDKV NMIGICGISG IGKTTLAKAI YNLMYVHFEG
SCFCEDVKEI ATRGGLIQVQ LHMIGKIMKI EDLKISSVGE GIMVIKKMMS SKPILLVLDN
VDDHEQLEAL ASSPDWFFSG SLVIFTSKYK QLLRSHKVNE LYEMETLNDY IALELFSLYA
FGKRHPTEDF QEVASQIVKY LQGHPLALKV FGRLLYDKSV YVWKSELDRL QTYPNSEIVQ
KLRPSFDSLA SDQKIMFLDI ACAFIGENKD FAASVLDTCH CSANAIIEVL ADKFLITVSA
DCLQMHELIQ SMSWEIIREE FRHNYRRLWI SAADYDVLNV NKVTEEVEVL VLSLKRNCQN
IPIDGQALTR MKNLRILKIC FPEVEGRWQQ FTVNISGRLD LLSYKLRLLH WHGLPLKFLP
SDFYPENIVT IDLSYSHIKH LWTTPKCFMR LKFMKLRYCC YLTSTPDFSK ITNLKELTLE
GCENLVKVHP SIGMLKKLVV LNMRNCKRLK SLPSKLEMVS LQILILSGCL KMEKLPEDLG
KIKSLTKLHI DRTSITELPL FDQQESFRSR WWTSIRGPFG LQSKQQHPQR SISMEGLHML
KSLNLSYCNL VQVPVSIGGL SCLEDLYLVG NNLFEVPESI GGLSCLKELN LAWNNLSEVP
ESIGGLSWNN FTSLPESLRQ LSHLKILRLD NCKKLEVFPE LPARLYFVSA CHCTSLSSVT
GSSKDPMMIN TSSFLSNCPK LLTNFAIESQ VSTSETECLD SYITSQGSTN EFSSFLRDAC
IQNNRCEFFR FPGSFVKEME IIYNGNSIPD WFTNKSMGNN VKVELPSDWC LDKFKGFGTC
VVFKQKNTLQ HVYCYLKNFD GALLQGWCVN SIEISESYRI CLLYTRDTKV WKYAKNFVKL
CFGENYDHGG GGYFYEDKSI EVKECGVRLI CDEGYEGIWN MRNNLLEVPE SIGGLSGIKC
LYLEGNNFTS LPGSLRQLSH LKILRLDNCK KLEVFPELPA RLYFVSACHC TSLSSVTGSS
KDPMMINTSS FLSNCPKLLT NFAIESQVST SETECLDSYI TSQGSTNEFS SFLRDACIQN
NRCEFFRFPG SFVKEMEIIY NGNSIPEWFT NKSMGNNVKV ELPSDWCLDK FKGFGTCVVF
KQKNTLQHVY CYLKNFDGAL LQGWCVNSIE ISESYRICLL YTRDTKVWKY AKNFVKLCFG
ENYDHGGGGY FYEDKSIEVK ECGVRLICDE GYEGIWNMSM LQDLPTLSQH GGAINLYGRR
GYIRSSW
//