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Database: UniProt
Entry: A0A2U1KJV7_ARTAN
LinkDB: A0A2U1KJV7_ARTAN
Original site: A0A2U1KJV7_ARTAN 
ID   A0A2U1KJV7_ARTAN        Unreviewed;      1447 AA.
AC   A0A2U1KJV7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=CTI12_AA594570 {ECO:0000313|EMBL:PWA37008.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA37008.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA37008.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA37008.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA37008.1}.
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DR   EMBL; PKPP01017385; PWA37008.1; -; Genomic_DNA.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR045344; C-JID.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11017:SF515; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF20160; C-JID; 2.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          10..178
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1447 AA;  165220 MW;  8F96A6BECCCCF498 CRC64;
     MATTSIPHRW KYDVFVSFRG DDIRKSFMDH MFNDFKQKGI HVFRDDIELP KGEEISPQLS
     KAIEESRFLI VIFSKNYASS SWCLRELVKI LDCKQMGKPK HEVQIIFYDV KPDVVRKQTG
     SYAGAFAKHD VSNRTEVGQW KEALSMAANL SGWDLQDMTN GFESKFIDSI SREILKKLCD
     GTLHVGENLV GIDIHFDKLD LSRFIGSDKV NMIGICGISG IGKTTLAKAI YNLMYVHFEG
     SCFCEDVKEI ATRGGLIQVQ LHMIGKIMKI EDLKISSVGE GIMVIKKMMS SKPILLVLDN
     VDDHEQLEAL ASSPDWFFSG SLVIFTSKYK QLLRSHKVNE LYEMETLNDY IALELFSLYA
     FGKRHPTEDF QEVASQIVKY LQGHPLALKV FGRLLYDKSV YVWKSELDRL QTYPNSEIVQ
     KLRPSFDSLA SDQKIMFLDI ACAFIGENKD FAASVLDTCH CSANAIIEVL ADKFLITVSA
     DCLQMHELIQ SMSWEIIREE FRHNYRRLWI SAADYDVLNV NKVTEEVEVL VLSLKRNCQN
     IPIDGQALTR MKNLRILKIC FPEVEGRWQQ FTVNISGRLD LLSYKLRLLH WHGLPLKFLP
     SDFYPENIVT IDLSYSHIKH LWTTPKCFMR LKFMKLRYCC YLTSTPDFSK ITNLKELTLE
     GCENLVKVHP SIGMLKKLVV LNMRNCKRLK SLPSKLEMVS LQILILSGCL KMEKLPEDLG
     KIKSLTKLHI DRTSITELPL FDQQESFRSR WWTSIRGPFG LQSKQQHPQR SISMEGLHML
     KSLNLSYCNL VQVPVSIGGL SCLEDLYLVG NNLFEVPESI GGLSCLKELN LAWNNLSEVP
     ESIGGLSWNN FTSLPESLRQ LSHLKILRLD NCKKLEVFPE LPARLYFVSA CHCTSLSSVT
     GSSKDPMMIN TSSFLSNCPK LLTNFAIESQ VSTSETECLD SYITSQGSTN EFSSFLRDAC
     IQNNRCEFFR FPGSFVKEME IIYNGNSIPD WFTNKSMGNN VKVELPSDWC LDKFKGFGTC
     VVFKQKNTLQ HVYCYLKNFD GALLQGWCVN SIEISESYRI CLLYTRDTKV WKYAKNFVKL
     CFGENYDHGG GGYFYEDKSI EVKECGVRLI CDEGYEGIWN MRNNLLEVPE SIGGLSGIKC
     LYLEGNNFTS LPGSLRQLSH LKILRLDNCK KLEVFPELPA RLYFVSACHC TSLSSVTGSS
     KDPMMINTSS FLSNCPKLLT NFAIESQVST SETECLDSYI TSQGSTNEFS SFLRDACIQN
     NRCEFFRFPG SFVKEMEIIY NGNSIPEWFT NKSMGNNVKV ELPSDWCLDK FKGFGTCVVF
     KQKNTLQHVY CYLKNFDGAL LQGWCVNSIE ISESYRICLL YTRDTKVWKY AKNFVKLCFG
     ENYDHGGGGY FYEDKSIEVK ECGVRLICDE GYEGIWNMSM LQDLPTLSQH GGAINLYGRR
     GYIRSSW
//
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