ID A0A2U1KJW2_ARTAN Unreviewed; 801 AA.
AC A0A2U1KJW2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=CTI12_AA593630 {ECO:0000313|EMBL:PWA37066.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA37066.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA37066.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA37066.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA37066.1}.
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DR EMBL; PKPP01017283; PWA37066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KJW2; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF600; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..177
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 801 AA; 91290 MW; DC90A1136B35CCE4 CRC64;
MSPSTRIRQR RKYDVFLSFR GTDTRNKFVS HLYNELARNR IDTFLDDEEL PRGSDIGPTL
LQTIGESRIA IVVFSKNYPD SSWCLNELLK IMQCHNDKEN RLIVYPVFYD VSPSDVRNQT
GLFGKAFSQQ NDHEKIDLWR EALKQCACQA GWDLNNPAGS HEANCIQEIV KNVFRVMDTV
MKTTDENLIG VERQMKNMMS LNSGGHDVGV IGILGMRGSG KTTIARAVYD MYEQEQFDGR
IFVQDISDDS KIPGGLVSLQ NKILFGILGH KRIQVNCVHM GCKKISQWLS RKKVLIVLDN
VDSREQLDAL AGARNWFGDG SIIIITTTDE RLLLATKLVN NTYNVSLLDD EEAIQLFSKH
AFHNGRPTEA HKECLERVIR YAAGHPGALK HLGCKLINKP INQWESLLDS LATCQTGIDN
MLETSLNGLT AWEKELFLDI ACFFNGWVKD EVIDILDSCG LFATSGLETL KEKCLITFSK
EFVQVHNLIQ EMGRHIVRQE NPDDFSRQSR LWRLEDVKDV LMENKGTEDI KAIVISNLHK
LDARGAFDAF TSMKKLRLLH ANTQRMVFQG IGSTCAEVQW IMQGSGCLKY LPCNLRWLTW
DYFNLESWPT DFHAKMLVGL QMRHSSIVDL FTKRDMKFLQ NLESLDLSFS KDLIRTPDFG
RLPRLKRLNL EFCSSLAEVH SSIGVHSKLV LLNLRSCEKL ESFPSRIKMG SLEFLNLSGC
SRLRKMPDFV NMNKLTELDL SHNSIEELPS SIGDLSSLVY LDVTNCRNLT SIPQSIWRLK
VQPEILLHGC PVPQDFLVRQ K
//
