ID A0A2U1KNE8_ARTAN Unreviewed; 296 AA.
AC A0A2U1KNE8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Non-functional NADPH-dependent codeinone reductase 2 {ECO:0000313|EMBL:PWA38183.1};
GN ORFNames=CTI12_AA583700 {ECO:0000313|EMBL:PWA38183.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA38183.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA38183.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA38183.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA38183.1}.
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DR EMBL; PKPP01015904; PWA38183.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KNE8; -.
DR STRING; 35608.A0A2U1KNE8; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 2.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF538; DEOXYMUGINEIC ACID SYNTHASE 1; 1.
DR Pfam; PF00248; Aldo_ket_red; 2.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 21..91
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT DOMAIN 116..267
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 58
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT SITE 88
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 296 AA; 33633 MW; EEEAA8FEC9DBD634 CRC64;
MLPAENIPNV ILSSGNKIPM IGMGTAYQVV DYDQVYVKQA ILEAIEQGYR HFDTSPNYMS
ESLIGEAIAE SLSRGVIHSR HEIFVTSKLW LTDAHSDLVV PALRSHPIKP EDLLPMDFES
VWRAMEDCQR LGLTKSIGVS NFTCKKLKYL LTFARIPPCV NQVEMNPVWQ QKQLRDFCSS
NGILVIAYAP LGAKGAHWGT NQVMDCKLLK EIALTRGKTI AQVCLRWVYE QGAGMVVKSF
NKERMKENLS IFDWELSDED YLKINKIQQQ RGMPKSRFVS ENGPYKSLEE LWDGEI
//
