ID A0A2U1KPC6_ARTAN Unreviewed; 736 AA.
AC A0A2U1KPC6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=NB-ARC domains-containing protein {ECO:0000313|EMBL:PWA38627.1};
GN ORFNames=CTI12_AA577680 {ECO:0000313|EMBL:PWA38627.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA38627.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA38627.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA38627.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA38627.1}.
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DR EMBL; PKPP01015436; PWA38627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KPC6; -.
DR STRING; 35608.A0A2U1KPC6; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..736
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015589383"
FT DOMAIN 11..97
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 183..321
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 328..396
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 736 AA; 83729 MW; C6532BE80EC5CBE3 CRC64;
MAVAEIFLGA FITVLFEKLA SADLIRLARA AGIYSELDKW NNTLSQIQAV LVDAGQKHIR
DNSVQLWLYK LQHLAYEIDD VLDDLATEAM RHQSNEESDA SSCTGTSKVL TMIPSCCTSF
TPRTIMYGGK MSFKLDEITT KLHSLVEEKN LLGLINNVER SNKTTRRLEE TSLVDLSIIV
GREGDKKALL EKLLSNEPCN KNFSILSIVG LGGIGKTTLA QVLYNDTKVK DHFKLMSWVC
VSDEFDVFSI SKAIYKDVGG EHKKFETLNQ LQVALTEKLS NKKFILVLDD VWNENYNEWE
LLQRPFAVGA PGSKIVVTTR KTMHALGKQN FESHPTLQSY GEEIVKKCGG LPLALRTLGR
VLRTKSTEEE WEELLNSELW HVQNGDKILP ALRLSYYDLP PHLKQMFAYC CLFPKDYVFD
KDEIVLLWMA EGFLYDSNGS KLMESLGREC FEELESRSFF QKSTNDKSRY IMHELINDLA
TSVAKEFFFM LGDKMDVYDM NEVLDKLHHM SFIRERYGVY RKFKALQRAR RLRTFLAMSV
TRLFTWQRFY LSEKVLTELL PQLRFLRVLS LANYNIREVP QSIGSLKHMR YLNFSNTDIK
CLPEVVGDLY NLQSLLVSGC PHLSSLPNSI IKLISLRHLD ISNTPKLNKM SSGFGGLTGL
QTLSKVVIGG ADEFKISDLK SLVHLQGQLS IEGLHKVINA VHAKEANLLQ KKGLRDLEMK
WSDNRNGGED CSGMQE
//
