ID A0A2U1KU71_ARTAN Unreviewed; 634 AA.
AC A0A2U1KU71;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=CTI12_AA564010 {ECO:0000313|EMBL:PWA40284.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA40284.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA40284.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA40284.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA40284.1}.
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DR EMBL; PKPP01013910; PWA40284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1KU71; -.
DR STRING; 35608.A0A2U1KU71; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd21037; MLKL_NTD; 1.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.20.930.20; Adaptor protein Cbl, N-terminal domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23315:SF49; U-BOX DOMAIN-CONTAINING PROTEIN 15; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 5.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 256..330
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REPEAT 388..430
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 470..512
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 634 AA; 70937 MW; 36031B6D19045600 CRC64;
MEEENVLSNA RVVRDVAEEL IGIIEGVKSM GEIRGTQKKE CQNLIRRLRQ CLPLMEELRD
LDAHIPEVCI SCLRKLKKAF ILAKKLLKTC HAGSKIYLIL EADAMVTRFH SVYDKLNHAM
DGFPYKEIGI SEEVNEQVEL MCMQLKKAKQ RMDSQDMELT TDMRAVLAAD SDRIMECDSI
KKLANRLSLN SLDELRIETV AIRKLVKERR GQNAEGTQKI IDLLDRFKRF AGIEQVNVLD
DPVPCNRSLQ KCTSIAIPFD FLCPITLEIM RDPVIIATGQ TYERESIQQW LDSNRRTCPK
TGLPLPHTAL APNVALRNLI IQWCKTNNYQ IPKKTPPPPP KKAHSEKVIT LIQNLSSSQL
QVQRKAVTKI RMLSRECTET RDLIAEKGGI PPLVRLLSYP DSKIQEHAVT ALLNLSIDDA
IKKQVSKEGP IPAIIEILQN GTVGAKENSA ATLFSLSMLD ENKVLIGSSN GIPPLVNLLT
EGTIRGKKDA ATALFNLTLS QSNKAKAIEA GAIKPLLKII ENDQLDMVDE ALSVLLLLLE
HPDGRKELGQ LSFVETLVKF MKEGTPKNKE CAAAVLLKLC TNNNNLMVIA LQYGVYEHVS
EISQYGTKRG KKKAMAILQL MSKRGQIPSY NNVR
//
