ID A0A2U1L1Q3_ARTAN Unreviewed; 266 AA.
AC A0A2U1L1Q3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Calreticulin 1b {ECO:0000313|EMBL:PWA42938.1};
GN ORFNames=CTI12_AA540470 {ECO:0000313|EMBL:PWA42938.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA42938.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA42938.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA42938.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: Molecular calcium-binding chaperone promoting folding,
CC oligomeric assembly and quality control in the ER via the
CC calreticulin/calnexin cycle. This lectin may interact transiently with
CC almost all of the monoglucosylated glycoproteins that are synthesized
CC in the ER. {ECO:0000256|ARBA:ARBA00037091}.
CC -!- SIMILARITY: Belongs to the calreticulin family.
CC {ECO:0000256|ARBA:ARBA00010983, ECO:0000256|RuleBase:RU362126}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA42938.1}.
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DR EMBL; PKPP01012109; PWA42938.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1L1Q3; -.
DR STRING; 35608.A0A2U1L1Q3; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0097602; F:cullin family protein binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.250.10; Calreticulin/calnexin, P domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001580; Calret/calnex.
DR InterPro; IPR018124; Calret/calnex_CS.
DR InterPro; IPR009033; Calreticulin/calnexin_P_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR024991; RING-H2_APC11.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11073; CALRETICULIN AND CALNEXIN; 1.
DR PANTHER; PTHR11073:SF2; CALRETICULIN-1; 1.
DR Pfam; PF00262; Calreticulin; 1.
DR Pfam; PF02171; Piwi; 1.
DR Pfam; PF12861; zf-ANAPC11; 1.
DR PRINTS; PR00626; CALRETICULIN.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF63887; P-domain of calnexin/calreticulin; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00804; CALRETICULIN_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU362126};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU362126};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 180..222
FT /note="Anaphase-promoting complex subunit 11 RING-H2
FT finger"
FT /evidence="ECO:0000259|Pfam:PF12861"
FT DOMAIN 221..263
FT /note="Piwi"
FT /evidence="ECO:0000259|Pfam:PF02171"
FT REGION 102..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 30294 MW; 881BE99E4BD825DC CRC64;
MKLLSGDVDQ TKFGGDTPYS IMFGPDICGY ATKKVHAILT YNGENKLIKK DVPCETDQLS
HVYTFILRPD ATYTILIDNV EKKTRSLYSD WDLLPAKQIK DPEAKKPEDW DDKEFIADPE
DKKPEGYDDI EKEIPDPDAK KDCLNGEFVR VGPNPKFAPV AGYHCSPPDM KVKLLRILTY
LWHAVASWTW DAHDETCGIC RMAFDGCCPD CKLPGDDCPL KLLDDYYTST TFQLKAQHII
IFRDGVSESQ FNQVLNIELE QIMQVK
//
