ID A0A2U1L4H5_ARTAN Unreviewed; 1047 AA.
AC A0A2U1L4H5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:PWA43906.1};
GN ORFNames=CTI12_AA532260 {ECO:0000313|EMBL:PWA43906.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA43906.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA43906.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA43906.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA43906.1}.
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DR EMBL; PKPP01011574; PWA43906.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1L4H5; -.
DR STRING; 35608.A0A2U1L4H5; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF602; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS)-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 10..159
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1047 AA; 119527 MW; 780BBE62BCF1DEE6 CRC64;
MASLSIQKSY EYDVFLSFSG EDTRKTFVDH LYDALRQQGI HTYKDDEQLK KGRRIKEELL
KSIENSVFSN YELVKIMECH KSTDQIAHPV FYDVSPSEVR KQHGAVGEAF AKHHKEENEQ
WREALEEAGN LAGWVLSNTA DGHEAKFIKK IVEEISLDLC SINLKANKKL IGMESRIKDI
VSSLEIGVDD VRMVGIKGMG GGGKTTLAKA VYDHICYQFE VVSFVENVRE VSKAPFSGLK
SLQKQVLSDV LHDHGITISS VSVGKNMMKR KLCGRKVLLV LDDVDHLDQL EALAGATNWF
KPGSRIIITT RDAQVLVAHR VKWIHNVNLL MHEEAICLFS RYAFGRDTPI QGYKRLAFKV
LRYAAGLPLT IRVLGSFLCG KNELEWIDAL ERLKTIPLKE TLEILEVSYI GLEDSYKEIF
LDVACHLKGA PKTYAIKMLE SCGFHARNAL RVLEQKSLIT MSNCDQYLGM HDHLEEMGWN
IVRRLHPDEP NKHSRLWIQE EINDILANNL GTEEIRCIQA WQPLKVSPEI AIKGFGNMKK
LRFLSMASFK INFDVKIDEV SQNFPNALRF LSWEGYPHWS LPRLFLANNL VTLEMPYSRI
AQLWGLGRGR KKESLGVLYL TELHLSVSDR SVRCSDNGLP MHWLKFCYKE PPSSFRNIEK
LVSLDGCCTL ENFSEGVCCL QHLRKLTLNG SIAKIPMDID YLECLEELHL SCTHIKLLPE
SICTLKHLKS LELKSCFGLQ KLPEDIFKLE KLEKLSCSNT GIKFLPDSIC MLETLKYLKI
DAKFLEKLPG NLGRLESLEK FCLSSAKINN FPDSICMLRH LRSLEVKSCV LRETLPKDFG
WLQYLEKIYL SYADIEYLPD SICMLKRLKS LKLILCWKLK KLPDDIGQLE CLENLILSGC
ESLEYIPNSI CKINRLRYFC LLSCTDVVEL PEEIGCLKCL EELDNTSSVD HLDFCNQYTI
LGWRNLLLCI MVRPRMPIAK SYYISFWAPK SPAKKTCSSI LYGCIDPVVP VKTKGRPKRA
IRVKPGFEVS LDLKKKNSCG YCGKKRS
//
