ID A0A2U1LV13_ARTAN Unreviewed; 954 AA.
AC A0A2U1LV13;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:PWA52817.1};
GN ORFNames=CTI12_AA450480 {ECO:0000313|EMBL:PWA52817.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA52817.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA52817.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA52817.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA52817.1}.
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DR EMBL; PKPP01007640; PWA52817.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1LV13; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF544; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS), PUTATIVE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 13..177
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 930..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 108479 MW; E16E23B2C8B241FA CRC64;
MAASSTSSIQ KSFKYDVYLS FRGEDTRKNF VDHLYHALQQ QGIHVFKDDV KLARGIAIGD
QLVESIEDSK IFIIIFTKNY ASSSWCLNEL VKIMECNKMN EHTVYPVYYG VEPTEVRKQS
GAVGDAFNKL KNKEDAGKWR EALKEAADLA GWELNNTFDG HEAKFIKKIV EEISIELRAG
SDSTNLTGVE NLVGMEARIQ DLEFHLELGV DDVRMIGIWG MGGAGKTTLA RALFDRISIQ
FEGKSFVEDV GQVSKPSLSG LKLLQMHVLS DVLDDKGITI ADIKEGKYMM RNLLHGKKLL
IVLDGVDDIE QLEALAGTPE WFGAGSRIII TTRDKQVLLA HRVSYIHGVS LLSDAEALYL
FSKYAFGRET PIQGYTDISL EVLRYADGLP IAIKVLGSFL NGKGEVEWMD ALERLKQIPL
KETLEKLEIS YISLEEDYKE IFLDVACFMN GWDKDYAIGI LESCGFHARN GLRVLEQTSL
ITMSNQSLSM HDQIQEMGKN IVRRSHPVEP NKHSRLWIEE EIGEILANDL GTEATYSIIV
DSPVKLSSVI VTHSFRSMKN LRILHMASEL DDDYDYDYEV KIDQAHQNFP NALRVLSWVG
YPHYYLPETF QATNLVRLNL SYSRIVQLWE GEERKVLYNL RFLDLSFSRL TSIDLELTPN
LERLDLEGCD DLVQLYTPIG CLQKLRYLNL NGCSRINTIL FIKRLVSIEV LCLTRLFLEK
FPDIIPENYN NRLIEFQFRY NDIEELPSSI ENLQKLVYLD LHSCRKLRSL PKSICGLRHL
RSLKLYGCII EELPEDIGRL ESLEKLNLSF TRIKHLPDSI CMLKHLKNLN LSSCWNLEKL
PEDLGQLECL QDLILSECTQ VRDIPDSICM LKHLKSLNLS NCILLAKLPE GLGCLDLEVL
NVKGTGIKHL PRSIYLLKDL KIYGPTLGLR SRGSASTSQT LEPSSISKQK LDDR
//
