ID   A0A2U1M1C1_ARTAN        Unreviewed;       595 AA.
AC   A0A2U1M1C1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Camphene synthase {ECO:0000313|EMBL:PWA55055.1};
GN   ORFNames=CTI12_AA430590 {ECO:0000313|EMBL:PWA55055.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA55055.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA55055.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA55055.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA55055.1}.
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DR   EMBL; PKPP01006881; PWA55055.1; -; Genomic_DNA.
DR   STRING; 35608.A0A2U1M1C1; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR   GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR   Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR   Gene3D; 1.50.10.130; Terpene synthase, N-terminal domain; 2.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR034741; Terpene_cyclase-like_1_C.
DR   InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR   InterPro; IPR001906; Terpene_synth_N.
DR   InterPro; IPR036965; Terpene_synth_N_sf.
DR   InterPro; IPR005630; Terpene_synthase_metal-bd.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR31225:SF9; 1,8-CINEOLE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR31225; OS04G0344100 PROTEIN-RELATED; 1.
DR   Pfam; PF01397; Terpene_synth; 1.
DR   Pfam; PF03936; Terpene_synth_C; 1.
DR   SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR   SFLD; SFLDG01019; Terpene_Cyclase_Like_1_C_Termi; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF48576; Terpenoid synthases; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT   DOMAIN          35..101
FT                   /note="Terpene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01397"
FT   DOMAIN          212..440
FT                   /note="Terpene synthase metal-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03936"
SQ   SEQUENCE   595 AA;  69864 MW;  CE0A70D0A4B4182E CRC64;
     MASMCAFASP FLVSNSENLT HGCLKTNATF SWYVHGEKYA PRLETLKEEV RTKIYKENEK
     AENPLSTLKL VDDLQRLGIW YHFVDDISNV LDKIYLRILR MRQVISKDTR LKILLDENIL
     DEARDFTTKY LQGSLGKIND QYLSSLTSRV LDMPLHWRIA QVETKWFIKA YEKRSGMNPT
     VLDLAKLDFN MVQAVHQEDL KHASRWWRTT KWDDKLSFAR DRLVENYMWT IGNSYRPQFT
     LLRIILTKVF AIITTVDDIY DVHDVKMFLT YKWNIYLIEE LPDYMKICFL GFYNSVNDMT
     YTTLTDTRFF ILPYLQKAWE DLCKAYLVEA RWYHTKCMPT FKEYLDIAEV SISVPLMLTH
     ISFVMNVCST EEVIQSMDKI KNLIHYSSLI LRLADDLGTS SDERARGDTP KSIQCYMHET
     GATEEEARAH VRSLIIKVWQ KLNKERAGLK TTYLKEFGEC AANFGRMAQF IKHAKIGQQG
     TGYKHHSFGC SRHHFGIECL HSNKYGCLLL FSSYQDNLSF KLSAKWIWSH IKVFKVEKYW
     TQYVLHFQND MELAGRTLKG ISKSVNHLIQ KAETQDPKSL MKLLXKNDYN DMYIY
//