ID A0A2U1M4D9_ARTAN Unreviewed; 571 AA.
AC A0A2U1M4D9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN Name=MLO {ECO:0000256|RuleBase:RU280816};
GN ORFNames=CTI12_AA420330 {ECO:0000313|EMBL:PWA56126.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA56126.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA56126.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA56126.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. {ECO:0000256|RuleBase:RU280816}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU280816}. Plastid,
CC chloroplast membrane {ECO:0000256|ARBA:ARBA00004508}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004508}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion.
CC {ECO:0000256|RuleBase:RU280816}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC ECO:0000256|RuleBase:RU280816}.
CC -!- SIMILARITY: Belongs to the RETICULATA family.
CC {ECO:0000256|ARBA:ARBA00010793}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA56126.1}.
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DR EMBL; PKPP01006562; PWA56126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1M4D9; -.
DR STRING; 35608.A0A2U1M4D9; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR InterPro; IPR021825; RETICULATA-related.
DR PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR31942:SF77; MLO-LIKE PROTEIN 14; 1.
DR Pfam; PF03094; Mlo; 1.
DR Pfam; PF11891; RETICULATA-like; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW ECO:0000256|RuleBase:RU280816};
KW Plant defense {ECO:0000256|RuleBase:RU280816};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 455..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 377..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 63415 MW; 73CB45BE9ECFF562 CRC64;
MDTLRGIVVD FFTVWLPAPT LSFISFADDA NGPDSIDALK GLLGSIPDNA FQKTLAGKDW
NVGHRVASVV VGGIKLAGVG FISSIGASAR KFLNPALVNN QQNKRSPILK TTVVYSGFLG
TSANLRYQQW IDLTRFTGLQ TQKSESSIII NQIIECANPA TIGCNNTEGF TGLQTQKSES
SINQTIESAN TATIGCNTTE EAGVDEIERV CITSQYPTQA VRMISTAGAS QLTSQSEDPK
IIDGQVDVIK IRKEVKYSAV CSKKPRLSED GNVISALSSR SSNKDTVCSI ISTDDKFTEN
GGDVSKSVPD VASAIEDLLE QTSKIHDQNS PERWQFDNFF SMPLLEVAKW PGWGFTSELG
LDLNSEDPHS AFGLSKHWTR SSKSDENPGG EENAGIYGGF SETQTESQLV LLLGAKLQHV
IATLALESAG ITGYFTEARL KPRDELFWFK KPQLLLRLIH FILFQNAFEL ASFFWFWWQF
GYDSCFLKHH TLVYIRLILG FAAQFLCSYS TLPLYALVTQ MGTNYKAALI PQRIRETIKG
WRKEARRRRK KEEESWAYTV TIRLFKRKLA L
//
