ID A0A2U1MH42_ARTAN Unreviewed; 1107 AA.
AC A0A2U1MH42;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=CTI12_AA377640 {ECO:0000313|EMBL:PWA60595.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA60595.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA60595.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA60595.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA60595.1}.
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DR EMBL; PKPP01005314; PWA60595.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1MH42; -.
DR STRING; 35608.A0A2U1MH42; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11017:SF586; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 23..192
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1088..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 126192 MW; 4C6FF688B05270E7 CRC64;
MVMDGALVSS SSSSSAAAPA KRWTYDVFLS FRGEDTRNNF VDHLYSALDH AGIYTFKDDE
KLQRGNSISP GLVTAIQESM VAVVVFSKNY ANSCWCLDEL VKIIECQDLM GQKVLPVFYD
VEPSDVRGQK RSFYTAFQQH EVKSRDDMEK QNRWRDALVT AANLSGWDVS RTANGREAEC
IKQIVRHILS YIESRPAENL IGMESRVRHV KSLLCKGVDD VYMIGIWGMG GIGKTTIARA
VYHQVSYEFD GSSFVEDVRE NGTDKRGLKS LQEKLLSEIL MQEHFKLKDC DDGVSQIRRR
LGRKKVFVVL DDVDSITQLE FLAGAHEWFG PGSRILVTTR DEHLLCYAQK KYAPELLKPT
EAMRLFSRYA FKANTPSNGY EVLSDAVVTH TGYLPLALKV LGSYFCGRNL EFWQSALNIL
AKKPNKEING ILKLSYDCLD DFEKEIFLHI ACLFKGKKRY YVTRILDSLG LEAVRGITVL
IEKSFMTISN GYIHMHDLIQ EMGLCIGREC FPDKIVWAPE EIKEVVTNVT KLENVEAIVE
KDRYFNERRP VPYSSAEVFK RMKKLRLLQV KGGFTFSEPT HFPEQLRWLC LVKYPFQSLR
ITRGMAKLVG LEIQEAQIKQ LEIEKKVTLT NLKFMILSGS SAINSFPDVS GVPNLESLNL
SYCSRLVEVH RSVLLHEKII NLNLNCCYNL KRLPPIIKMK SLQTLHLMGC MHLERLPEIS
RETRRLLLLN ISGCGGIMAL PSSTRLLTAL TILDMGNGME LSFGKENFFS KRILPNELDN
QDPILFISLR ILDLRLNNLV EDDFSTNLHN VWPSLEELVL SRNVITRLPA SISQLSHLKY
LNLSCCINLK ELCELPSLIQ FLKADNCKYL EKIGDLSSKC RWLFKISLYS CPKLLEDQES
QSYLTNMLMK SLVQKCAAVN HQLSIAVPGS KIPNWFTKQQ LVFHNKIMLN LPKSQITRVK
GLALCFLLRL NWPDPTWFEI KFNTSNEEVL IVRPQHAAKT ANHVWIGYMS ITFLENLCDG
FESEYLILSV NSCLNDLVEC GLCVVYKDDV IPMTEIGSWI PDYDDSGKIN HYCVDDEDFQ
HGRWSQPSLS YGKDRPGAHN SSVHVEL
//
