ID A0A2U1MJ49_ARTAN Unreviewed; 821 AA.
AC A0A2U1MJ49;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein-tyrosine-phosphatase MKP1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CTI12_AA376620 {ECO:0000313|EMBL:PWA61249.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA61249.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA61249.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA61249.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA61249.1}.
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DR EMBL; PKPP01005149; PWA61249.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1MJ49; -.
DR STRING; 35608.A0A2U1MJ49; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14498; DSP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR46381; MKPA PROTEIN; 1.
DR PANTHER; PTHR46381:SF4; MKPA PROTEIN; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 150..292
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 209..270
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 89789 MW; B9C376F17FDE3763 CRC64;
MLGKEDEVVE EGGGGGGGGN ESVGGVGSVS GGRKVYWRSA SWSSSHVPLP PLVPEKEGVG
GSGRRPVALT PRSNSKGRSC LPPLNIARRS LDEWPRAGSD DVGEWPSTPC GGRDLNNGER
LKLDLSAIQR VPDKNGGLVK RDRIAFFDKK CSKVGEHIFL GGDSVARDKD ILKQHKITHV
LNCVGFVCPE YFKGNFVYRT LWLQDSPSED ITSILYDVFD YFEDVREQGG RVFVHCCQGV
SRSTSLVIAY RMWREGQSFD DAFQFVKAAR EIADPNMGFA CQLLQCQKRV HAIPLSPSSL
LRLYRIAPHS SYDPLHLVPK MLNVPSPAAL DSRGAFIMHV PSTIFIWVGK KCESLIERDA
RGAVCQIVRY EKVQGPIVVV KEGEEPTYFW DAFSSLLPLM DKSGNAMDIA KFSNVNPGER
LVDSYSIDFE IIHKASVGGF VPPFGSSETD QETHLPVKES SWSVLRRKFA VGNMKEFVLA
SKSSPSRVYP DSLFLGADNN SNSNFSSKPV ARSSTSSLIS SSSLSPSFSL ASSPDSMSSD
SSISSKCYSD SPAASPSVTS YTHPFSSTLS TLSNLSLVPT KLSPHSISKS SDFIDVNFTS
KSCSQSVLSP SKKSSLSIAE RRGGTPKSLK LPISSDESEC QDDAESNGDI VLEVKLKGLN
KESRRQDSRS LCPNSEGDGL DRDETCNASQ GNRSSKRKES ESAHHNVKQQ VVVLEWPSLE
NVTRFNAGDM DSSRLYIFVV SSSISGKNGD SVVYLWVGKA FRHDCRNLLE TNKRFADLPD
FAVKEVTNNV VSRMGLSKET RVKVVKQDEE PSDFVAILSS L
//
