ID   A0A2U1MWC9_ARTAN        Unreviewed;       535 AA.
AC   A0A2U1MWC9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=Toprim domain, Twinkle-like protein {ECO:0000313|EMBL:PWA65540.1};
GN   ORFNames=CTI12_AA173780 {ECO:0000313|EMBL:PWA65540.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA65540.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA65540.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA65540.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA65540.1}.
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DR   EMBL; PKPP01004202; PWA65540.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1MWC9; -.
DR   STRING; 35608.A0A2U1MWC9; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   CDD; cd01029; TOPRIM_primases; 1.
DR   Gene3D; 3.40.1360.10; -; 2.
DR   InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR027032; Twinkle-like.
DR   PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR   PANTHER; PTHR12873:SF6; TOPRIM DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13662; Toprim_4; 1.
DR   SUPFAM; SSF56731; DNA primase core; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT   DOMAIN          205..273
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|Pfam:PF13662"
SQ   SEQUENCE   535 AA;  60788 MW;  C6DFB9A1AA3B8F92 CRC64;
     MSYLKRLPKY PCHVRKTRII YSKRKRQGKL SDICISFAQH LEIVALVNEN INASFDKQTD
     FVCKGGQSKE RSLWFHKDQN EKLSMWRCSN LECEWAAAHE DAGPKKDEIN KDNILPKPSE
     ETLRLEPIGD ELIKYFAGRQ ITADILQKNV MQKISNKSVI AFTYRRNGEL VSCKFRNSKI
     KEYWQAKNGE KILYGLDGIK EGNDIVIVEG ELDKLSMEQA GIPNCVSVPD GAPQKVSKKL
     PTKREDSNLR YLSDCYGHVD KASRIVLATD GDQCDNVLRR CIALYNSITY FLGFLRCWRV
     TWPKKDESSC YKDANEVLVH LGAEALRHIV ETAEKYEILD DPTADEVNKK PSEETLRLEP
     LGDKLIEYFA GRKISADILQ KNAVMQMIDD KNVIAFTYRR NGELVNCTFY SITSRKLWQA
     KNGERILYGL DGIKEGNDIV IVADELDKLS MEQAGIPNCI SLPVSALQKA SKNALSDKRK
     DLKFKYLLDC NGVKNASRII LATHGNRPGP GLAELSSVLG KERFVIKMFK KTINE
//