ID   A0A2U1MZT6_ARTAN        Unreviewed;      1367 AA.
AC   A0A2U1MZT6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Toll/interleukin-1 receptor (TIR) domain-containing protein {ECO:0000313|EMBL:PWA66772.1};
GN   ORFNames=CTI12_AA327240 {ECO:0000313|EMBL:PWA66772.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA66772.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA66772.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA66772.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA66772.1}.
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DR   EMBL; PKPP01003966; PWA66772.1; -; Genomic_DNA.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF340; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Receptor {ECO:0000313|EMBL:PWA66772.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT   DOMAIN          13..178
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1367 AA;  156993 MW;  0CF9788D198498DE CRC64;
     MEPTSTTSVQ KSFKYDVFLS FRGEDTREDT RNTFVGHLYK ALVQRGIQTY KDDKKIEKGK
     TIDKQLIKSI EESRFFIIVF SKDYASSRWC LNELVKIMEC QKTSDERIAY PVFYHVEPRE
     IRNQSGAVGE AFKKHENDED ATKWRDALND AGKLAGSELK GDESILIEEI VDIIFKKICS
     SNSSVDENLV GMVTRREAVL SSLELDADDV RMIGIWGMGG GGKTTLAKVV FDRIFIHFDG
     KAFVENVKDV SKSSLGLKQL QQQILCSVLS NKDINVNSVH EGTNMMKNLL RGRKVLIVLD
     DVDDIEQLEV LAGKHDWFKS GSRVIITTRD QQVLVAHQVK FINDISLLSP AEAICLLSKY
     AFNRDIPVVG YEELSQEVVQ YADGLPLTIK VLGSLLCGQN VPYWKETLAR LKKIPLKATM
     KKLELSYDGL ENDHKEMFLD VACFLKGRKE EDAVIVLESC GFFPKVGLEV LKQRSLITIS
     GGELGMHDHI EEMGKNIVRR ENPNKPEMHS RLWIKEEIED ILANGSGTQA TTQCIKLFAP
     GGLNYEILMK GLANMKELRF LYVVSPFVSF EEVRKWKFDE DSLHLPNALR FLRWDYYPFS
     SLPKTFQPNN LVGLEMNFSR MVKLWKDGEE KPFLKLRFLK FTISPHLRTL DLSVAPNLET
     LFLEDCYNLV EVHFQKVRKW KFDEDSLHLP NALRFLRWSW YPFSSLPKTF QPNHLVGLEI
     HFAKMVKLWK DGEEKPFLKL RFLKLTNSHV VRTLDLSVAP NLETLILDQC FDLEEVHFQV
     TPNLKELSIN YCYRLEELQM PAESPKLRSL DLRDLKKLRV TPNLETLRVT DCADLVELQV
     PAECPKLINL NLSNCVKVAE LPEEIGRLEC LKELDITGTG LSRLPESIFG VKGLRIVGSR
     QLLEHQKQKS PVPWSSDDFE HLQRPKEEYK VYFIESDLRK SIFRQNLKSE TRDAAILIFP
     CGMTGYKGVG SEEEVSNWSF DEDSLHLPNA LRFLRWDAYP FSSSKKRSPF LKLRFLKLTW
     SRYLRTLDLS VAPNLETLNL DYCKNLVEVH LQVTPNLKEL RINYCYRLEK LHMPAESPKL
     RSLDLYNLKK LRTLHLGVTP NLDTLRVRDC PDLVDLQIIP AESPKLRSLD LYNLKKLRTL
     HLGVTPNLDT LRVTHCADLV ELQIPAECPK LVNLDLSNCI QVVELPEEIG RLECLKELDI
     TGTGISHLPQ SIFRMKGLRI VGSRWLLEHQ KQKSPVPWSS DDFEQLQRPK EVTALRTFLT
     GIQSYFIESD LRKSIFRQNL KSETRDAAIL IFPCGMTGYK GDFICGLQFF GLHLKGTPDA
     TKGLDQLECP EQLIEELPEE NGRLECLEEL KRTGIGINHL PQSTFWL
//