ID A0A2U1NDA9_ARTAN Unreviewed; 879 AA.
AC A0A2U1NDA9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Disease resistance protein {ECO:0000313|EMBL:PWA71461.1};
GN ORFNames=CTI12_AA279680 {ECO:0000313|EMBL:PWA71461.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA71461.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA71461.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA71461.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA71461.1}.
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DR EMBL; PKPP01003081; PWA71461.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NDA9; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022667};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 10..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 192..426
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 879 AA; 100648 MW; B0F6B210013976E8 CRC64;
MADLITSALV SDVVARLTSA AFQEVGLLWG LENDLSALNN TFRQIQGVLH DAEMRQTNEK
AVEEWLRTLK SASLEVENVL DEASTEAMIQ SLDSIKHKAR TYFFTRHNPL VVKTRIAHKV
KNIRKKLDVI DANRSRFQLI PTNIREDAAG IGSEISKWET SSLMSKICGR DEEKNLIVDK
ICNPDIGITR DDDDVRVYAI WGMGGIGKTT LAQYVYNHET VKTHFELKCW VYVSAVFDVQ
RIVKQIIKVL CDPEYLKDLK LDEMSLDDLE RKLETKLSGK KYFIVLDDVW IENNEKWKEL
CKPLSCAEKG STVMVTTRKK NTAQLMAKIP ELQRNVGELS EEESWALFKM FAFPDRGERE
NVSSELELVG KKIVEKCNGL PLAVITMGSL MLTKEKKVNE WQHVNDNFKW AQDDDIVLPA
LRLSYNDLPP RMKICFAYCC VFSKGEEMNK DSLIELWIAN GFIPSEGGMS SYVLGQKIFT
FLVQRSFFQD VVEKDIDTGA ICKMHDLMHD LALDVMKHDC AVIEPGKESR IPDEVLHLSL
SCEDFQFSKQ DLKKLRSVRS MFVYNIDYRS NITQISNHVY LRVLYLNEIK CLTLPESICK
LIHLRYLKIS ESKIVVLPES IINLQNLQVL ILEKCWELRE LPKGLRYMRN LQRLDASCHL
VRHIRELTNL RRLPEFSVGK DDGAQIGELG NLNRLGWKLK SGTFDSEVVE GLEPNSGLQE
LEIRDYNGRV LSPSWLVKLV NLTSILFTSL FRCEQLPPLG KLPSLKIIKV DFMPSIKCFH
DEDNSTSKDE ILFPSLQELE IESCRSLVSL PNNFPKLQSL KIERCHKLGS LPDEIQSFKD
LNQITIKGCA ILSRRCEKGI GEDWPKISHI PHIDITTSR
//
