ID   A0A2U1NID1_ARTAN        Unreviewed;      1172 AA.
AC   A0A2U1NID1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=RNA-directed DNA polymerase, eukaryota {ECO:0000313|EMBL:PWA73265.1};
GN   ORFNames=CTI12_AA262640 {ECO:0000313|EMBL:PWA73265.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA73265.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA73265.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA73265.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA73265.1}.
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DR   EMBL; PKPP01002763; PWA73265.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1NID1; -.
DR   STRING; 35608.A0A2U1NID1; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR026960; RVT-Znf.
DR   PANTHER; PTHR46890:SF1; FGR14P; 1.
DR   PANTHER; PTHR46890; NON-LTR RETROLELEMENT REVERSE TRANSCRIPTASE-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF13966; zf-RVT; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:PWA73265.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:PWA73265.1};
KW   Transferase {ECO:0000313|EMBL:PWA73265.1}.
FT   DOMAIN          440..717
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   1172 AA;  135139 MW;  40E4DE54DFD22B4A CRC64;
     MEFPAVRNCW GNLTFNYIHS NSVGNSGGIL CVWDLNSFTK VSHTLSDYFV IIRGKWLKND
     TDIMFVAVYG PHDPRDKRMV WEYLTHVINQ WNGNVVVMGD FNEVRFKSDR FGSIFNVQGA
     DDFNSFIEDA GLEEVPLGGS AFTWCHKSAT KMSKLDRFFI SNSLLNSCPH VSAITLDRFL
     SDHRPILLCE TNFDYGPIPF RFFHHWIKLD GFSTFVSDVW NSAPVNKDNG MRNLAGKLKF
     LKGKLREWIK SSRVKGKSDS SNLKEELRVL DETIDKGDRS DGLIQRRMEI MNDIQYLDQL
     HAMELAQKSK IKWAIEGDEN TRFFHGVLNK KRNQMAIRGV LVDGKWIDQP SDVKMEFFNH
     FRDRFSKPVE NRITLELAFP KQISRDQQNE LERMVTKEEL KMAVWDCGTD KSPGPDGFSF
     GFFRHFWSIL EKDVFEAVSH FFVHGDIPPG CNPSFITLIP KVPAANMVKD FRPISLIGCL
     YKIIAKILAN RLVGVLEDIV HEVQSAFIAN RQILDGPFII NEVHQWCKSK KKQSMLFKVD
     FEKAYDSVRW DFLDDVLNKF GFGNKWRNWI HCCLKSSRGS ILVNGSPTEE FQFYKGLKQG
     DPLSPFLFIL IMESLHISFQ RVVESNMFKG IKLSDSLCIS HMFYADDAVF VGNWSDENIN
     TLTHVLDVFY RASGLKINMC KSKILGINVD VHKVNQAANK LGCLILSCPF SYLGSKVGVS
     MSRIEDWREV IDKVKCRLSK WKMKCLSIGG RLTLLKSVLG AMPIFNMSIF KVPAKVLKML
     ESIRGRFFNG HESDSRKAYW IKWDKVLANK DKGGLGVSSF FALNRGLMFK WVWRFLNNES
     SLWKKVIKAI HGDGGNIHNA TRFGINSCWS SIVKEAQNMK SRGINIFDYL KLRLGKGNSI
     KFWDDDWYQG GILKDICPRM YALETRKDVT VCEKMKDPSI CFSFRRGIRG GSEQDQFNHL
     EAVSNSITLG PREDRWVWSL EGSGEFSVAS LRRKIDDIHL PNVGTKTRWT KLVPIKVNVL
     AWKVMVDALP TRWNLSRRGI NIPSMLCPIC GIGVESSSHL FFRCEVSRHI GQSLAKWWDI
     PVQDVVSYDD WKGWLISIRL GSKLKGVLEG VWITMWWYIW WYRNKMLFDD NPPKKACLFD
     RIVTSSFQWC RSRCKSSLDW NEWLKTPYLI SL
//