ID A0A2U1NK38_ARTAN Unreviewed; 1417 AA.
AC A0A2U1NK38;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NBS-LRR resistance-like protein {ECO:0000313|EMBL:PWA73883.1};
GN ORFNames=CTI12_AA257340 {ECO:0000313|EMBL:PWA73883.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA73883.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA73883.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA73883.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA73883.1}.
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DR EMBL; PKPP01002660; PWA73883.1; -; Genomic_DNA.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1237; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 12..94
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 175..393
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1417 AA; 160286 MW; 373F1A15B5A28F28 CRC64;
MAELVLSALL PVVFEKLTSV LEKKITRSKG IHSELKKWET KLTLIRALLS DASQKEIKDE
AVKLWLNGLQ HLVYDIDDIL DALATDAMHR ELVKESQPIT ITNKVRKFIP SCCTSFSLST
KVGSKLDEIS TRLQELMDEK DKLALIVKNE VSKDRNRGYQ TSLEGGRGIV GREGDKKELV
QKLLSDESCN ENFGIVPIVG MGGIGKTTLA RALYNDQLVN DHFEFKAWVC VSDDFDSFKI
SKVIYQEVGG EQKDFVDLNR LQVALRDQLM GKRFLLVLDD VWSDKWEDWK TLEGPFFAGA
SGSKIIITTR KKELLRKLLN HDHPYILEKL SPDDALSLFA QNALDKNNFD LFPELRPHGE
GIVQKCDGLP LALEALGRLL RNRTDEEEWK RLLANEIWML EDDGGILPAL RVSYHDLSAC
LKQLFAYCCL IPKDYMFEKK DLILWWMAEG FLHNSATNKT MECLGEEYFQ ELLSRSFFQQ
APDDESLFVM HDLMNDLATF VAGEFFSRLD IDMEKNVRKE AFKKYRHMSF VCETYMTYKK
FKAFERDNRL RTFLAMPNVL NSWQTFHLSS KILVDILPQL PLLRVLSLSR SYIDEVPECV
GNMKHLRYLN LSQTDITHLP ESVCNLYNLQ TLIVYGCHSL TTFPNNFSKL KNLRHFDIRD
TLLWNKMPLG ISEMKSLQTL SNKVAVVENN DFFISWLRNL KNPQAEIYID ELQKLQSARD
IQEVNLSQKR VSKLHMGWSN AFDDRNEELE KEVLDELKPH SVNLEDLAIV SYGGKLFPNW
MGDPSFLHLT SVRIEKCGKC MLLPPLGELP SLKKLVIQEL NEVKVVGSEF LGTGIAFPKL
ESLSITNMRG WEVWSTKSGV VGAVTFPCLE VLQIEECPNL AKISLEALPS LRELEINCHK
LAEVSLEGLP SLRVLHLSGC GNGLLISLIH AASAVTKLII SHITGLSDEV WRGVMDYLGA
VEELSIGVCN EIRYLWESEA EASKVLVNLR KLEVDGCSKL VSLGEKEDGC NQLTSLRILE
LRLCQSLERC NLPNSIEELT IFNCPLIASA SFPTGEGHKL KSLEIFNCEQ LLEKDVLLNT
SMPAMLEVVD ISSWKNLKSI NELTCFIHIT KLEITECDCI ESMVELTGFI HLTELRIYYC
SNIESFPAAD LLNLTSLTHM SILWCKSMDV DSFGVWPPNL GSLSIGGLKK PISKFGPQNF
PPSLVHLVLS GGSAEEEEDD VTGGSQLSHM LPSSLTKLRL WEFEKLESVS TGLQHLTSLQ
HLIIDKCPKM KDLPEELLTS LLSLYIDGCT NELKEKTSGK RGCQEVPEVG NFRSVAILVY
TNHKEQNSVS AIGHYFSHLK HLEIGGCRGL VIDFQIALYM IGNADTLKKV VIDPSTNRAD
ESVLTTEESL KREEAGRSHA KYDLSQCLPP WVELVIL
//
