ID   A0A2U1NKJ6_ARTAN        Unreviewed;       622 AA.
AC   A0A2U1NKJ6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=RNA-directed DNA polymerase, eukaryota, Reverse transcriptase zinc-binding domain protein {ECO:0000313|EMBL:PWA74034.1};
GN   ORFNames=CTI12_AA256430 {ECO:0000313|EMBL:PWA74034.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA74034.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA74034.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA74034.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA74034.1}.
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DR   EMBL; PKPP01002636; PWA74034.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1NKJ6; -.
DR   STRING; 35608.A0A2U1NKJ6; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR026960; RVT-Znf.
DR   PANTHER; PTHR46890:SF1; FGR14P; 1.
DR   PANTHER; PTHR46890; NON-LTR RETROLELEMENT REVERSE TRANSCRIPTASE-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF13966; zf-RVT; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:PWA74034.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:PWA74034.1};
KW   Transferase {ECO:0000313|EMBL:PWA74034.1}.
FT   DOMAIN          1..162
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   622 AA;  72100 MW;  0325639A8701A0E1 CRC64;
     MDQMGFPPRW CLWIRGIIQS ARSAVLVNGS PTFEFYCQKG LRQGDPLSPF LFLIVMEALT
     NMILRACRLG DVEGIKVSDE GPSISHMLYA DDALIMGTWS RNNIVMNTRL LRIFFMCSGL
     KINVHKSHLF GLGVSDTEVS SMAEVLGYKV GSLPFQYLGI KVGANMNRSS HWDPVVETVR
     NRLQSWKAKV LSIGGRLTLI KSVLSSLPVY YLSLFKAPGV VLENIERMMN KFLWTGSREG
     RGIHWVSWDI VTRPKRFGGL GISKLSEVNL ALLVKWMCWF KTDHEGWWRK FIISLHGGRN
     RWAFLPVKKA LAGNWKSVVN FLEKTRINGE SIDKFFTCQL GDGSRINFWK DIWYGTTPLC
     IRWPILYSKD RNKKVSVKER IRFDGTVLVL DDSWELDAST VEGISEVQDV SYMLSQVKYS
     GCTDRWIWDQ NPNADFSVAA VKNSLRRYIY TQQAHQMIWV KWVPIKVNIL MWRIEKGRVP
     TRLELVKRRM VLPDSRCPLC RLEEESVNHL FITCEFSFAV WSLIWRWCKL IPVHFDSITD
     LVQGQELLLA SARGKELFRG ITMVTCWAIW KERNEMVFQN STPKVVEVVS RVKSMSFLWF
     NSRAYSLKVV WKEWVKYPMY ML
//