ID A0A2U1NMC5_ARTAN Unreviewed; 762 AA.
AC A0A2U1NMC5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Calcium-dependent channel, 7TM region, putative phosphate {ECO:0000313|EMBL:PWA74659.1};
GN ORFNames=CTI12_AA249110 {ECO:0000313|EMBL:PWA74659.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA74659.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA74659.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA74659.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA74659.1}.
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DR EMBL; PKPP01002531; PWA74659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NMC5; -.
DR STRING; 35608.A0A2U1NMC5; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF125; CALCIUM-DEPENDENT CHANNEL, 7TM REGION, PUTATIVE PHOSPHATE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..173
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 194..356
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 367..639
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 725..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 87421 MW; 4275002A1992F905 CRC64;
MATFGDIGLA AVINIITALI FLLVFAFLRL QPINDRVYFP KWYIKGLRKS PTASGAFVRK
FVNLDYRSYL KLLNWVPDAL KMSQSELIEH AGLDSAVYMR IYLLGLKIFV PIFFITWAVL
IPVNWTNNTL KLSKETYSEI DKLSISNIPH GLWAHVAVAY VVTIWTCFML KKEYETVANM
RFYFLQSEKL RPDQFTVLVK NIPPDAHESV SDIVQNFFLA NHHNNYLTHQ IVCNANKLAK
LVKKRQKKQN WLDYYQIKHS KHPSKRPLMR TGFWGLWGKK VDGIEHHETE IEKLTNEIAK
ERKNVLNDPK AILPAAFVSF KTRWGAAVCA QTQQVRNPTS WLTERAPEPR DVYWKNLAIP
YVSLTIRKVI MGVAFFFLTF FYMIPIAFVQ SLANIEGIEK VVPFLKPIIN VKLIKSFIQG
FLPGIVLKIF LMMLPKLLMR ISKFEGFISI SKLERRSASR YYLFKFVNVF LGSIIAGAAF
EQLHAFLNQP ANKIPETIGI AIPMKATFFI TYIMVDGWSG TAGEILRLKR LIIYHLKNIF
LVKTERDRQR AMSPGSIGFN TGEPQIQFYY LIGLVYAVVT PLLIPFILVF FALAFVVYRH
QIINVYNQKY ESRAAFWPDV HGRVITALII SHVLLMGLLS TKHAVASTPV LLALPILTIG
FHIYCKGRFE PAFTRYPLQE AMNKDTLDLV SEPRPNLKGY LQNAYIRPVF KDGGSDDHYN
DRTMIVPTKR QSSRNTPEPS KTSGDSVASL HEIIDESISH EY
//
