ID A0A2U1NRW0_ARTAN Unreviewed; 507 AA.
AC A0A2U1NRW0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE SubName: Full=JAB1/Mov34/MPN/PAD-1 {ECO:0000313|EMBL:PWA76255.1};
GN ORFNames=CTI12_AA232230 {ECO:0000313|EMBL:PWA76255.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA76255.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA76255.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA76255.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA76255.1}.
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DR EMBL; PKPP01002290; PWA76255.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NRW0; -.
DR STRING; 35608.A0A2U1NRW0; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF18; AMSH-LIKE UBIQUITIN THIOESTERASE 3; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 333..463
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 109..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 57653 MW; 73A6FAA455AE8C17 CRC64;
MRPPVKNRTE LNAMARKIDV DHRIPLRNYY RIADNLLKQA RIYREENNIM DLYVMLLRYS
SLVLDTIKFH RDYQVLCPKE RAYCRKQLLV VMDELESVKA EVDRQLDYNN TRSEEYQPNG
RGTADRSEVS SFHLPGVNNR VSFGSDNKQS HKKESPLSWH QNLGGTQDKQ SSANGIQFQK
LSLLPPPRQE TLSRHSFLGP NGLRSQWSGP SAQIKVQYPT YDLNSSDHLS LIQSAQSDIP
GIKDSNSGVD TMDSVLSLDD GRWSRPAAEE FSSQFDVDDF LSGNIRQPSP PPVLARLQPE
HTHISPAQVA DPRPGPANLF QDDAHTSTTY QHLHIPVKMM QDFLRLAQEN TKRNLETCGV
LAGSLKNRNF QITTLIIPKQ ESTSDSCQTL NEEDIFDVQD KRSLFPLGWI HTHPSQTCFM
SSVDLHTHYA YQIMLPEAIA IVMAPTDESS PHGIFHLSDP AGVNLIRNCD QRGFHPHEEP
DDGSPIYEHC SHVYMNETLN FDVVDLR
//
