ID   A0A2U1NVT4_ARTAN        Unreviewed;       876 AA.
AC   A0A2U1NVT4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=P-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:PWA77567.1};
GN   ORFNames=CTI12_AA221380 {ECO:0000313|EMBL:PWA77567.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA77567.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA77567.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA77567.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA77567.1}.
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DR   EMBL; PKPP01002108; PWA77567.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1NVT4; -.
DR   STRING; 35608.A0A2U1NVT4; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR045529; DUF6469.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF442; P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE-RELATED; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF20073; DUF6469; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:PWA77567.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT   DOMAIN          111..202
FT                   /note="DUF6469"
FT                   /evidence="ECO:0000259|Pfam:PF20073"
FT   DOMAIN          247..598
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          605..805
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
SQ   SEQUENCE   876 AA;  99084 MW;  61FB24344DCC468A CRC64;
     MATTSCSSRK PETKDLELID VVFSWSVDDV LNKNLYRDKV IRIPETFSST ADYTKSFIDP
     LLEETHAELL STMELISRAS TREILSVSRK IKDDKSSKYY FYSMELKTTS RNENYEPEVG
     DLIALTYGKP RFAHDLSRAN ESPYVIALVQ WVDEVNEAIK IISSNPILFS RKESNKGGKS
     MFFAVHLMNM TTNTRIWKAL HSRLDGKNMK IINKVLHSDS KGTERCSHCC NKDNNSSDLK
     EVMSTLNLNA SQQRAVLSCI TARECHHQES VNLIWGPPGT GKTKTVGCLL FTLWKMRCRT
     LTCAPTNSAV KEVAARLVSL VRSALDNGTY GVGDIVLYGN NERMKIDGSH ELNQVFLEHR
     ISVLASCLSP TYGWRSNAES MIHLLKYPKD EYDSYLNTEK KENDENRNDE KRMIKSFSEF
     ITKRFNVLEE NLTTAVRNLY THMPTSFVTL ELAKKMMKVI SLIQSIGTLV PGNDGIQNIL
     EGADNSKKKT MTLTKIQVMR KEFLRVLDQV LCQTVSFPKF RDEQAIRNFC LEKACLIFCT
     VSSSIRLHTL KTNIELLVID EAAQLKECES LIPLQLAGLR DVILIGDEKQ LPATVQSKIC
     MKAELGRSLF QRLVMLKHTT HLLNIQYRMH PMISLFPNKE FYNKKILDGP NVKERSYKKQ
     FLKGKMFGQY SFIHLAQGEV EFDETKSKKN MVEVAVVIEL VTKLHKESIT KNQKISVGCI
     TPYKAQVLAI QGKLGDLYGT REAVESKFSV NVRTVDGFQG CEEDVIIIST VTGKRNGSIG
     FLSTPQRANV ALTRARHCLW ILGNGDTLMR SSPIWKRLVT DAKARCCFHE GNKDKTLDQV
     ITNNLIKHGN LSKRMAEMSL VKEVGLISSS SSKAPS
//