ID A0A2U1NWL0_ARTAN Unreviewed; 673 AA.
AC A0A2U1NWL0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=MSCS-like 2 {ECO:0000313|EMBL:PWA77878.1};
GN ORFNames=CTI12_AA220250 {ECO:0000313|EMBL:PWA77878.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA77878.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA77878.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA77878.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA77878.1}.
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DR EMBL; PKPP01002064; PWA77878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NWL0; -.
DR STRING; 35608.A0A2U1NWL0; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR045042; YnaI-like.
DR PANTHER; PTHR43634:SF2; MECHANOSENSITIVE ION CHANNEL PROTEIN 2, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43634; OW CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..355
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 498..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 74561 MW; FC5457779AD00F3D CRC64;
MSMTGSLTSH KWGIYKNQRY NKQFENVMCT RQGLIRSDRI HILPASLSSL ASRQDSLSIN
LSVRLHRPLT AASNRLNLLK CNCSLNPSLA FGTSSVKNAA LALSSALQGK PIILKLLPAV
GIVVFAVWGI GPLMRRSRNL FLHKSDASWG KSSTNYVMTS YLQPLLLWTG ALLLCRALDP
VVLPSEASQI VKKRLLTFVK SLSTVLALAY CLSSAIQQTQ KFFTETSDAT DTRNMGFQFA
GKAVYTAVWV AAVSLFMELL GFSTQKWLTA GGLGTVLLTL AGREIFTNFL SSVMIHATRP
FVVNEWIKAK IEGYEVSGTV EHVGWWSPTI IRGEDREAIH IPNHKFTMNV VRNMTQKTHW
RIKTHLAISH LDVNKINVIV ADMRKVLAKH PQVEQQRLHR RVFLENVDPE NQSLLILISC
FVKTSHHEEY LCVKEGILLD LLRVISHHRA RLATPIRTVQ KIYNESDLDS YPFADSVFTR
GRAPTNRPLL LIEPSYKVNS EDKSKSQNSK IKSNSKAEGK SGGAPSDSKT KDKPTSDVKS
VDKITADAKE DPVTDKKLNP DTPISDKNVE PSSSSDGKPR NKAVESDINQ ADSRKAVESE
KSSATEQKPS RPAMEENIVL GVALDGSKRT LPIEEEIDTE VKELSRSASG KGPPSSDKDK
KDGNTHSNKS TDK
//
