ID A0A2U1NWV6_ARTAN Unreviewed; 587 AA.
AC A0A2U1NWV6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=O-methyltransferase COMT-type, S-adenosyl-L-methionine-dependent methyltransferase {ECO:0000313|EMBL:PWA78002.1};
GN ORFNames=CTI12_AA049170 {ECO:0000313|EMBL:PWA78002.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA78002.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA78002.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA78002.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-independent O-methyltransferase family. COMT
CC subfamily. {ECO:0000256|ARBA:ARBA00034481}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA78002.1}.
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DR EMBL; PKPP01002049; PWA78002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NWV6; -.
DR STRING; 35608.A0A2U1NWV6; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR012967; Plant_MeTrfase_dimerisation.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF303; F5F19.5 PROTEIN; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF08100; Dimerisation; 1.
DR Pfam; PF00891; Methyltransf_2; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PWA78002.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:PWA78002.1}.
FT DOMAIN 22..73
FT /note="Plant methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF08100"
FT DOMAIN 198..294
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT DOMAIN 307..444
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
SQ SEQUENCE 587 AA; 65258 MW; 38EFBCD92CD3FBB2 CRC64;
MDSNEDHFTY AMQLVTSTSL TMVLVNAIKL KVLEAIAKAG PDARLSAYEI AFRLSIPNKD
APNMLDWMLR LLASHSIVTC TQSCHNLSPV RVYGLAPVAK YFIGSKDGVS LGTFMELYQD
DVCMHTWSKL KDSVLEGGVA FDKLYGRHLF EYPAIDARFN DVFNNAMVNH TTIVINEILD
CYHGFENLKR LVDVGGGIEH IGGDMFQEVP HGDAIFMKWI LHDCQCVKLL SNCYKALPHD
GIVIVVEAVL PFLSDTSSSV KVTTHMDTMM MTQCPGGKER TDEEFLALDK DAGFTGIRKQ
CFVCNLSKLK DSVLEGGISF DKVYGIHAFE YPAVDARFNN VFNNAMVNHT TIVIKELLKC
YHSFENLKQL VDVGGGLGIT LNMIVLKHPT VKGINFDLPH VIRHAPVYPG IEHIGGDMFQ
EVPHGDAIFM KWILHDWSDV QCVKHTSSSI KATTHLDAMM MTQNPGGKER TDEEFLALAK
DAGFGGIRKS CFLKVLDTIA EVGTDVWLSA YEIVSRLSIS QIRMHQTCLT GCLDCSQAIP
LSLALNRTNN IMSPNQVYGL APVPNMLDRM IRLLASYSIV TCTQQDE
//