ID A0A2U1NZV0_ARTAN Unreviewed; 1045 AA.
AC A0A2U1NZV0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Calcium-dependent channel, 7TM region, putative phosphate {ECO:0000313|EMBL:PWA79045.1};
GN ORFNames=CTI12_AA073410 {ECO:0000313|EMBL:PWA79045.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA79045.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA79045.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA79045.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA79045.1}.
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DR EMBL; PKPP01001906; PWA79045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1NZV0; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF123; CALCIUM-DEPENDENT CHANNEL, 7TM REGION, PUTATIVE PHOSPHATE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 24..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 936..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..113
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 134..183
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 346..505
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 526..678
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 689..952
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 608..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 119163 MW; E7B0C3AA5D086291 CRC64;
MGHCKPGLVT CRILPWRIVC NRGLFVPSIV SLTVPLALMS FSSIRMFTVA SVLCLFIVLP
VNLLGQGIEV IDPETQMDIF TIRNVQEGSR GLWAHFFALY VISICAYALL YIEFKNVARM
RLEQVIRFPT KPSHFTVLVR GIPWSTEESY SEAVRKHFSS YYNSSYLAHQ MVYRSGTIQR
LMEHVPELLL LNNKKIIIPP SFRYHLLLSM FSYSGQYPAV SRQDPARTGQ DPVKSGYIRL
EPAKSGCCDP LCSADETSSQ DYEDTYQPIT KALAIFGAAA TGAVAINQSW VAANQDLAMA
ILFEIGYAGI IFEESLVFNK SGVGLLMAVS LWVIRSIGES EMILPALLTS AGFNIVICVG
FMSLYSILRK QPYNLKVYFG QRLAQLQPGQ KNHYFFDRMI PSAGWLVKAW EATDEDIYAC
GGVDGLVFIR LIVFCIRMFT VASVLCLFIV LPVNLLGQGI EVIDPETQMD IFTIRNVQEG
SRGLWAHFFA LYVISICAYA LLYIEFKNVA RMRLEQVIRF PTKPSHFTVL VRGIPWSTEE
SYSEAVRKHF SSYYNSSYLA HQMVYRSGTI QRLMMETEKM YKVLTETTIN QYVQPITVGI
GIPTNPFKTG TSESESASKK DKHEAKSHKK EQEECPAAFV FFRTRYTAMV ASRIIQSKDP
MLWVIDFAPE PHDVYWPNLC VPYRLLWIRK TLVYIGSILF SLWFLLPTTL VQGLINIASL
ERTIPVLRGI STWKYVNIIS GYLPSLVLMC FVLLVPPVML IFATLEGAVS RSGRKKSACC
KVIIFFFWNI FFYNLFTGTW WDRMGKLTVT GMKDMATLLG NLIPGQAPFF MTYIMTSGWA
TLAYELMQPF VLIVNWVYQF VLMRKEGYGD RYTFPYHTEV PRALLFNLLG FTFCILAPLI
LPFLLVYYFF AYFVYRNQIL NVYITRYNTN GSYWPVAHNA AIFALIVMQS VASIIFSMKK
FTTASIMAFI LIIFTSLFNL YCRHKFLPLF TNKAVQDLIE MDRHDEHAGK VEEILSRLLS
SYNYKVGSYS GNHPTDLLAA EYKKV
//
