ID A0A2U1PF17_ARTAN Unreviewed; 444 AA.
AC A0A2U1PF17;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Magnesium transporter {ECO:0000256|RuleBase:RU366041};
GN ORFNames=CTI12_AA159030 {ECO:0000313|EMBL:PWA84332.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA84332.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA84332.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA84332.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: Magnesium transporter that may mediate the influx of
CC magnesium. {ECO:0000256|RuleBase:RU366041}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU366041}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU366041}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC
CC 1.A.35.5) family. {ECO:0000256|ARBA:ARBA00007535,
CC ECO:0000256|RuleBase:RU366041}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA84332.1}.
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DR EMBL; PKPP01001240; PWA84332.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1PF17; -.
DR STRING; 35608.A0A2U1PF17; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProt.
DR CDD; cd12823; Mrs2_Mfm1p-like; 1.
DR Gene3D; 2.40.128.330; -; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR InterPro; IPR039204; MRS2-like.
DR PANTHER; PTHR13890:SF41; MAGNESIUM TRANSPORTER; 1.
DR PANTHER; PTHR13890; RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|RuleBase:RU366041};
KW Magnesium {ECO:0000256|RuleBase:RU366041};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366041};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366041};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366041}; Transport {ECO:0000256|RuleBase:RU366041}.
FT TRANSMEM 380..401
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366041"
FT TRANSMEM 413..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366041"
FT COILED 223..250
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 444 AA; 50211 MW; 6E43D10F7274AD28 CRC64;
MGDLKERLLP KPASAMNLGG DASNRPFASF RQPFLGVDAI GLKKRGQGLR SWIRVDAATG
DSQIIEIDKF TVMRRCDLPA RDLRLLDPLF VYPSTILGRE KAIVVNLEQI RCIITADEVL
LLNSLDSYVL QYVVELQRRL KASNEVWQSD ASDLNKWKGS RDFGDVSRNA SSDYLPFEFK
ALEIALEAAC TFLDTQAAEL EIEAYPLLDE LTSTISTSNL ERVRRLKSRL VALTRRVQKV
RDEIEQLMDD DGDMAEMYLT EKKMKMDTLS YGGDQSISGY RLSDGPHTVS APVSPVSSPP
DFRKLEKSFS FARSRHESMR SSESTAQNIE ELEMLLEAYF VVIDSTLNKL TSLKEYIDDT
EDFINIQLDN VRNQLIQFEL LLTTATFVVA IFGVVAGIFG MNFPITLFDS PSAFEWVLLI
TGVTGLVLFC SFLWFYKSRR VMPF
//
