ID   A0A2U1PFA7_ARTAN        Unreviewed;      1034 AA.
AC   A0A2U1PFA7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Putative acyl-activating enzyme 1, peroxisomal {ECO:0000313|EMBL:PWA84435.1};
GN   ORFNames=CTI12_AA157160 {ECO:0000313|EMBL:PWA84435.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA84435.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA84435.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA84435.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA84435.1}.
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DR   EMBL; PKPP01001229; PWA84435.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1PFA7; -.
DR   STRING; 35608.A0A2U1PFA7; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43859; ACYL-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR43859:SF4; BUTANOATE--COA LIGASE AAE1; 1.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        567..589
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          256..289
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   DOMAIN          436..509
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   DOMAIN          701..774
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   1034 AA;  115559 MW;  1F54D01B9B8B748A CRC64;
     MVLRSTFKAF QDDYIDFHYN SVSLDFHGSM EDWVMEQILV AVLAPNIPEM YELHFAVPMA
     GELLCTLNIC YDSTMVSTLL KNSDAKLIFV DYQFLDVAKG ALEIISESMP TIPQLVLIPD
     SEKLSILPKS EIMEDEALWQ WEILILRSED RMMTQGSTYV SLRTVNVKDI FECISHHKVT
     HMGGAPTVLN MIINAPASEK LPLPGKVSMM TAGVRGVSLM WSHRNIWFRN SLHMETRVEL
     PTTGHTSENQ ITTSTMESVI FRHPAVLEAV VVGRPDGHWG ETPCAFVKKK VCMDLCNRSV
     RASGCLCTCL LFLKGKVNFR TVNAKDIFEC ISHHKVTHMG GAPTVLNMII NAPASEKLPL
     PGKLGFKVYH SCGLIETYGS ATVCTWKPEW NSLPPDIRAR IKSRQGVNHL GLEEVDIKDP
     VTMKSIMWDA KTIGTMESVI FRHPAVLEAA VVGRPDGHWG ETPCAFVKVK EGYKLNGDEL
     IAFCRKNLPH YVTPRIVVFE ELPKTSTEKT QKFILREKAK AMTNGEFIIK MKEQTIIRRR
     YAWIYATAQF VLVVVFALVF YSSKLHVPGI LSALLATFAG FGGATTFSAK DIFECISHHK
     VTHMGGAPTV LNMIINAPAS EKLPLPGKLG FKVYHSCGLI ETYGSATVCT WKPEWNSLPP
     DIRARIKSRQ GVNHLGLEEV DIKDPVTMKS IMWDAKTIGT MESVIFRHPA VLEAAVVGRP
     DGHWGETPCA FVKVKEGYKL NGDELIAFCR KNLPHYMTPR TVVFEEFPKT STEKTQNQKK
     VCMDLCNRSV RASDCLCTCL LFFKGKVNFR TVNAKDIFEC ISHHKLTHMG GALTVLNMII
     NAPASEKLPL PGKVSMMTVL EAAVVGRPDG HWGETPCAFV KKKVCMDLCN RSVRASGCLC
     TCLLLLKDIT GLKCKLFCEK RSTFTPTSSI TITKNTHNLK PNNKNLTIRL IHLKHYNNNN
     PMLQLSVDVA THQKSDATAL AHGPDVTRVL KYDIGYLCSI MFIIEVASRA FRQVSKDESY
     DFKNLQFRST VSGL
//