ID   A0A2U1PNB1_ARTAN        Unreviewed;      1252 AA.
AC   A0A2U1PNB1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Serine/threonine-protein kinase, active site protein {ECO:0000313|EMBL:PWA87251.1};
GN   ORFNames=CTI12_AA133820 {ECO:0000313|EMBL:PWA87251.1};
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA87251.1, ECO:0000313|Proteomes:UP000245207};
RN   [1] {ECO:0000313|EMBL:PWA87251.1, ECO:0000313|Proteomes:UP000245207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC   TISSUE=Leaf {ECO:0000313|EMBL:PWA87251.1};
RX   PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA   Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA   Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA   Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT   "The genome of Artemisia annua provides insight into the evolution of
RT   Asteraceae family and artemisinin biosynthesis.";
RL   Mol. Plant 11:776-788(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWA87251.1}.
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DR   EMBL; PKPP01000933; PWA87251.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1PNB1; -.
DR   STRING; 35608.A0A2U1PNB1; -.
DR   Proteomes; UP000245207; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 3.
DR   InterPro; IPR045272; ANXUR1-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR025886; PP2-like.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR27003; OS07G0166700 PROTEIN; 1.
DR   PANTHER; PTHR27003:SF358; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (VEGFR2)-RELATED; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 3.
DR   Pfam; PF14299; PP2; 1.
DR   SMART; SM00220; S_TKc; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 3.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 3.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:PWA87251.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW   Transferase {ECO:0000313|EMBL:PWA87251.1}.
FT   DOMAIN          17..326
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          350..623
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          646..925
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   1252 AA;  143720 MW;  A5E1E752F1AE50DD CRC64;
     MDHLRIPLSD IESATNNFSA NRIGSGGYGT VYKAELDIFD DTISSVPDGK NKADFPKKRK
     TVAVKRLERK HGEVAGFFTE IEMLTNCKHQ NIVSLLGFCE EGPERILVYE HVSNGSLSDY
     FEKINNRKRL SWAQRLQICL DIAQGLDYLH SNTEEKPMII HRDIKSDNIL LDNNWVAKIA
     DFGLSRLRPA NQKASTINTG TIAGTEVYLD PEYMETGRLK KESDIYSFGV VLFEVVSGKL
     AYDKSYCIKN EKGLLSIVQK CFSEGTLKKV IDPNLKEASE GILILDDGLD QKSLDIFLDI
     AYQCLAHTQD RRPTMKVIIN ELEKALNYQE NRKDGFHISL KDITSATKNF NDETCIGEGR
     YGKQYEGRIP LENIPTTVII KRWDKESHQA HPRFLTELKV VSENKHENIV ALVGLCYESG
     ERIIVYEHAT KGTLDKHLKD VNLTWIKRLK ICVGIATGLK FLHEDAEINH RDIKSSSILL
     DADWEPKICN FEISSTTQEW LKAEHATDNA YGSLGYLDPL HEKQGYLDKY SDVYSLGVVL
     MEILCGRLAW GEGCKDHSES LGPLTKRRYK EGKLDELVFE GIKEQFSSQS FTTFASIAVQ
     CLKRQDYIRP EASEVVIQLE KALELQERCE KLQISLEDIK LGTENFSDAK FIGEGRYWKQ
     YKGHIPHANG LTTVVVKRFD TKCDEGSKQF IVESEALFEY KHKNIIHLAG ICEEVNEKII
     VYEHASNGRL SEHLKDTNLT WLKRLKICIN VATGLRFVHT DNVRSFEART HGNIKSGSIL
     IDGEWKAIIT NLELLKSEFT TLKTSQLDEI YAYNSFGYIG PEYNKHGFMT RASDIYALGV
     VFMEILCGRL AWEDGCKDPS ACLGPLAKRR YQEGNIDELV FEGIKKQIDK KSLTTFTDIA
     IRCIGYYWLE RPYPRDVIIE LQKALEYQED YETWEPKLPR DYKELLHFSK IDEMEKFKDI
     YNTLCKGIHL RDREVGLSRS YCGSDAIFVE GIEFEPIDNL KEEDIKKTMA IQQQLPTYSE
     KRSGNDYEGG ELLPLNEVNV KKHFMLSAME VLYDCSNVEP FHLEPSAKSR NAHCRLQLQR
     SHLHLRRSHL HLLRSHLHLR RTTCTSGDLV APPETGTRFQ EVIELLPQQV SGIKSKIRSR
     MLSPDTDYAC YLVFKLSEKC RGLHCPVRVR NVLQWKDKEI GLVWFRPPNQ WNSHDTYWVP
     KRREDGWMEV RVWNFNSTSA LRTGRIPMHL KLITYEGTMS GLIVRGLEIR PV
//