ID A0A2U1PQP0_ARTAN Unreviewed; 960 AA.
AC A0A2U1PQP0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CTI12_AA123990 {ECO:0000313|EMBL:PWA88079.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA88079.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA88079.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA88079.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA88079.1}.
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DR EMBL; PKPP01000849; PWA88079.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1PQP0; -.
DR STRING; 35608.A0A2U1PQP0; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR PANTHER; PTHR45786:SF7; OS12G0539700 PROTEIN; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 307..473
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT REGION 59..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 109989 MW; 4DC3C896127ADEAC CRC64;
MSQGSQEQNK GIPSLSGMLH NSLLIYSKTF VSQHGRLQSY CGLKLTEFGG AITGEASTTL
DTSTNLPLSQ MPSTSKSPFE YKKRRSSGPS YLRATRKTQE RAAFSSSDNS VNTGRGPYTF
RINGQSYHRI GSLLPAQGTQ PKYAQLYFFD TGREVKNRIG AFIGKENAEG VDEKIVARLI
KMFDQSSSIA KAFRMARDWC ESQNSAKFEL HLLSGRSATR QYNAPTVPEI AALITNDFGD
GIPTRDIIIS NKNEGLKRIS ELHPEYMALQ YPLLFPYGED GFHEKIQYHN NTGTRKTKRD
CVTMKEYYSY VIQQRNNQGT TLLRGGRLFQ QYLVDAFTAV EEQRLKWTRK NQDTLRVDLY
HNLCDAVTRG DTSAAGIGKR IILPRTFIGS PRYMMQNYQD AMAICRTYGN PDLFITFTAN
PKWPEIAEML KHIPGQKGID RPEVATRLFK IKLTEMLDDL TKHHIFGQTR AVMRLNYHLP
NQNAVTIRDS ENLPALIQRE GIDITMFTDW FELNKRDTNA KSYTYAEIPM HYVWHEKDKM
WKERKTQKSI GRIHYSHPAS GERYYLRMLL NIVRGPESFE KLMTVNDRLC STFKEACFAY
GLLNDDTEWK HAISEASVWA FGPQLRDMFV TILLFCDVSR PIKLWEENWQ ILSEDILHKK
RKIFKYPELQ LTDEQLQNYC LIEIQELLNR NGKSLAEFKD LPLPNPKLLT KLDNHLIREA
LDYDMKKSGT GKTFLYKTII SRLRSERLIV LAVASSGIAS LLLPGGRTAH SRFVIPLELL
ENSTCGIKQN THMAELMQEV KLIIWDEAPM TQKYAFEALD KTLKDILGFH DPDCRNRIFG
GVTVLLGGDF RQVLPVIPKG SRADIVQSCI NQSDLWKHCK VFTLTRSMRV NEYTENGQID
TCKQDFNKWV LAVGDGTVPA KCKEATRLTT TIYEEHRKPI HSVYTEYATA VQKNKPKICY
//
