ID A0A2U1Q0R5_ARTAN Unreviewed; 527 AA.
AC A0A2U1Q0R5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN ORFNames=CTI12_AA089060 {ECO:0000313|EMBL:PWA91610.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA91610.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA91610.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA91610.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA91610.1}.
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DR EMBL; PKPP01000532; PWA91610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1Q0R5; -.
DR STRING; 35608.A0A2U1Q0R5; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PWA91610.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 527 AA; 59171 MW; DE6218E714A78228 CRC64;
MEINQTTMMM TSSLVDSMLF GASRALCSPF AVFIQIQGCV ICLLLALGWA GAAYVRNREI
RQMKKAMKDG NHFAFLSHDL DDLEHSKQVQ LPGVTVVMPL KGFGEHNLHN WRTQLTSLYG
GPLEFLFVVD STEDPAYHAV SRLLLDFNDD VDARIIIAGP STTCSQKIHN QLVGVENMHK
GSKYVLFLDD DVRLHPGSVG ALTAEMIKNP EIFIQTGYPL DLPSGSLGSY CIYEYHMPCS
MGFATGGRTF FLWGGCMMMH ADDFRTDKHG VVSGLRDGGY SDDMTLAAIS GAHKRLITSP
PVAVFPHPLA SDLTFSRYWN YLRKQTFVLE SYTSYVNYIM NRALFSVHCY LSWGFVSPYI
MAIIHVTAAL RFHFKDNLSE EPLLNPNGLR LVGGLVICTA IELLSMWNLT RIEVRLCNML
SPEAPPLSLG AYNWSLVFVA MVVDNFLYPI SAIRSHFSQS INWSGIRYHL RNGKIHKIDR
TMEKGKKFSD LAAKRLYARK GAQSKISILG SFSRSLAQWR QPKKFDV
//
