ID A0A2U1QE94_ARTAN Unreviewed; 569 AA.
AC A0A2U1QE94;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE RecName: Full=uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288};
GN ORFNames=CTI12_AA041780 {ECO:0000313|EMBL:PWA96283.1};
OS Artemisia annua (Sweet wormwood).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC Artemisiinae; Artemisia.
OX NCBI_TaxID=35608 {ECO:0000313|EMBL:PWA96283.1, ECO:0000313|Proteomes:UP000245207};
RN [1] {ECO:0000313|EMBL:PWA96283.1, ECO:0000313|Proteomes:UP000245207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Huhao1 {ECO:0000313|Proteomes:UP000245207};
RC TISSUE=Leaf {ECO:0000313|EMBL:PWA96283.1};
RX PubMed=29703587; DOI=10.1016/j.molp.2018.03.015;
RA Shen Q., Zhang L., Liao Z., Wang S., Yan T., Shi P., Liu M., Fu X., Pan Q.,
RA Wang Y., Lv Z., Lu X., Zhang F., Jiang W., Ma Y., Chen M., Hao X., Li L.,
RA Tang Y., Lv G., Zhou Y., Sun X., Brodelius P.E., Rose J.K.C., Tang K.;
RT "The genome of Artemisia annua provides insight into the evolution of
RT Asteraceae family and artemisinin biosynthesis.";
RL Mol. Plant 11:776-788(2018).
CC -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC uroporphyrinogen-III to yield coproporphyrinogen-III.
CC {ECO:0000256|ARBA:ARBA00002448}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen
CC III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00001082};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWA96283.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PKPP01000187; PWA96283.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1QE94; -.
DR STRING; 35608.A0A2U1QE94; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000245207; Unassembled WGS sequence.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 2.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 3.
DR SUPFAM; SSF51726; UROD/MetE-like; 2.
DR PROSITE; PS00906; UROD_1; 1.
DR PROSITE; PS00907; UROD_2; 2.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis {ECO:0000256|ARBA:ARBA00023171};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000245207}.
FT DOMAIN 59..68
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00906"
FT DOMAIN 185..201
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
FT DOMAIN 304..320
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
FT REGION 514..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 62350 MW; 8DCD6B98C7999A2E CRC64;
MSTMYTCSIP SFSLSNSTFP RPNRIICSAG VSVAERKAVN TSEPLLLNAV RGEDVERPPV
WLMRQAGRYM KAGLYNHIYL FHIYGDFCST LDLILVFVWQ SYQTLCEKHP SFRERSENVD
LVVEISLQPW KVFKPDGVIL FSDILTPLPG MNIPFDIVKG KGPIIFDPIS TADDVAQVNN
EAAVLGFVGA PFTLASYVVE GGSSKNFTKI KKLAFSQPES YQTLCEKHPS FRERSENVDL
VVEISLQPWK VFKPDGVILF SDILTPLPGM NIPFDIVKGK GPIIFDPIST ADDVAQVNNE
AAVLGFVGAP FTLASYVVEG GSSKNFTKIK KLAFSQPEVL HALLQKFATS MAKYIQYQAD
KGAQAVQIFD SWATELSPVD FEEFSLPYLK QIVDTVKQTH PTLPLILYAS GSGGLLERLP
LTGVDVVSLD WTVDMAEGRK RLGTDIAVQG NVDPGVLFGS KEFITNRIND TVKKAGKGKH
ILNLGHGIKV GTPEENVAHF FEVAKGLRIK KPPTTNEQLT EADLPLSIDE VIQEVSQTTT
DASSPPSSPS EGSSQQSVEE DVTVSPQST
//
