ID   A0A2U1SYR9_9MICO        Unreviewed;       821 AA.
AC   A0A2U1SYR9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=DF220_02210 {ECO:0000313|EMBL:PWB96775.1};
OS   Salinibacterium hongtaonis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Salinibacterium.
OX   NCBI_TaxID=2079791 {ECO:0000313|EMBL:PWB96775.1, ECO:0000313|Proteomes:UP000244978};
RN   [1] {ECO:0000313|Proteomes:UP000244978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S1194 {ECO:0000313|Proteomes:UP000244978};
RA   Liu S., Wang Z., Li J.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWB96775.1}.
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DR   EMBL; QEEX01000001; PWB96775.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1SYR9; -.
DR   Proteomes; UP000244978; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PWB96775.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244978};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          19..472
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          782..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  88311 MW;  3DD27445EB5449A9 CRC64;
     MTTPANRISD EPHERIDDVD LASEMEGSFL EYAYSVIYSR ALPDARDGLK PVQRRILFQM
     TEMGLRPDRG HVKSARVVGD VMGKLHPHGD ASIYDAMVRL NQPFIMRVPL IDGHGNFGSL
     DDGPAAPRYT EARLAAAAIA MTADLDEDVV DFVPNYDNQI MQPEVLPAAF PNLLVNGATG
     IAVGMATNMV PHNLIEVVGA ARHLLENPDA TLDDLMAFVP GPDLPTGGTI VGLSGVRDAY
     ESGRGSFKTR ARVSIEPITA RKMGLIITEL PYMVGAEKVI EKIKDGVGSK KLNGISDVAD
     LTDRKRGMRL VIGIKTGFNP EAVLEQLYKH TPLEDQFNIN NVALVDGGPR TLGLRELLRV
     YVDHRIAVTT RRSAYRLARR RERLHLVEGL LIAIVDIDEV IQVIRTSDDS EQARARLIDV
     FDLSHVQSEY ILELRLRRLT RFSRIELEAE RDQLAAEIAE LEKLLADPAL VRALVSRELD
     EAAEKFGTPR RTLLTEARAS IATSGRSKAA TPNLEIADVP CRVILSTTGR LVRVDYVDGE
     IHPIIAPARR SKHDAVLSEV VTTSRSDIGA VTNRGRVVRL SPVDLPVVPD NSVQLAAGRK
     AADYIGLDAK KERVLALVAL EPDMPLALGT RDGIVKRVSP FDIPNKPEFD IISLKDGDEV
     VGAAIASDDA ELVFVTSDAQ LLRFAASAVR PQGRSAGGMA GIRLSAGASV ISFSVVEDAD
     SAVVVTVSGS SATIAETDPG RAKVSALSEF PAKGRSTGGV RAHSLLKGED CLMLAWVGPQ
     PAMASGSDGS TRTLPEPGAK RDASGTPLPG VLGSIGRSIG S
//