ID   A0A2U1TDC6_9MICO        Unreviewed;       306 AA.
AC   A0A2U1TDC6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:PWC06874.1};
GN   ORFNames=DF223_09660 {ECO:0000313|EMBL:PWC06874.1};
OS   Mycetocola zhujimingii.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Mycetocola.
OX   NCBI_TaxID=2079792 {ECO:0000313|EMBL:PWC06874.1, ECO:0000313|Proteomes:UP000244962};
RN   [1] {ECO:0000313|Proteomes:UP000244962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=622 {ECO:0000313|Proteomes:UP000244962};
RA   Liu S., Wang Z., Li J.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWC06874.1}.
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DR   EMBL; QEFB01000009; PWC06874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U1TDC6; -.
DR   KEGG; myl:C3E77_00815; -.
DR   Proteomes; UP000244962; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd12166; 2-Hacid_dh_7; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244962}.
FT   DOMAIN          50..303
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          101..272
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   306 AA;  32794 MW;  5C2A9813196EF470 CRC64;
     MTDPLLVSVP GKTLRKAIGD IDGVRFVEWD LSGPAPESSF DIVILPYMGS PETLQALQGV
     TTKLVQSQSI GYDGMDEVLP PGNVFANASS VHETSTAELT LALVLAAQRG IPDFVRAAEK
     GKWAPARHAS VADRTVLLLG YGGVGKAIED RLLPFEVNVV RVATHARSDE RGEIHGIDEL
     PELLPTADIV IVGVPLTDET TGLVNEEFLS VMPDGALLVN IARGAVADTD AILRHAESGR
     LRFALDVTDP EPLPDGHPLF ALENVLISPH VGGASTAMMP RMAKLARRQI ERMLRGEEPE
     NVVLRS
//