ID A0A2U1ZUV6_9MICO Unreviewed; 938 AA.
AC A0A2U1ZUV6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=C8046_08810 {ECO:0000313|EMBL:PWD50730.1};
OS Serinibacter arcticus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC Serinibacter.
OX NCBI_TaxID=1655435 {ECO:0000313|EMBL:PWD50730.1, ECO:0000313|Proteomes:UP000245166};
RN [1] {ECO:0000313|EMBL:PWD50730.1, ECO:0000313|Proteomes:UP000245166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCH200 {ECO:0000313|EMBL:PWD50730.1,
RC ECO:0000313|Proteomes:UP000245166};
RA Thakur V., Kumar V., Singh D.;
RT "Genome assembly of novel Miniimonas species PCH200.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWD50730.1}.
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DR EMBL; PYHR01000002; PWD50730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U1ZUV6; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000245166; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 36..184
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 387..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..407
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 95770 MW; B6251854BC246BAB CRC64;
MTTALYRRYR PDSFADVIGQ EHVTDPLRAA LRADRATHAY LFSGPRGCGK TTSARILARC
LNCAEGPTDT PCGVCESCVE LARGGPGSLD VVEIDAASHG GVDDARDLRE RAVFAPARDR
YKVFIIDEAH MVTPQGFNAL LKLVEEPPAH VKFVFATTEP EKVIGTIRSR THHYPFRLVP
PAVLQGYLGT LCEAESITVD SGVLPLVVRA GGGSVRDSLS VLDQLMAGAA EEGVSYDLAS
SLLGFTPVTL LDDAVGALAA GDGAALFRVV DHVVESGRDP RRFVEDLLDR LRDLIVISAS
GSEAETVLRA LPADEVERMR PQASALGAHR LSTVADIVNA GLTDMVGATS PRLLLELVLT
RAMLAIGGLG DAPAAASHAT PVATIPAPIP APVQASTPEP TTPPVVTQPA TPSRASEAPQ
SRPAASATTA PPAQPAAAAI PGAGPLGGPR EGAPTPTRRP AERPATERQQ PAAEQTTTPA
PRSEERPAAR DEAPREPAAP ASPAAPAADQ PAAEPTSSAG AVDGTELRRR WPEVLETLAA
SSRATWTLIS QHAQPGEVTA DSMTLLFPTP GLISAFTGRD GGAVLSQAIF ETVGLRLRVQ
VDVAGPDGPG GPGGDGGPAG PGGGQGVGQG VGQGVGQGQR DGGGRNERAP QGGARADGQG
RGPLAQVPGA TAQAGPAHDF GPEPDEDPYG AHDPYLASEH AARAEPEPER APASPAPTAA
SPRIVTQPTA TTPRPSTTPT TRQPAPSEAQ PPAAAETAEP EAPARQVSEA VARALADWDD
APVAVPGRSS SATGGTAATP ADDSADDVPH VRSHLSVVAP MAPDAPDVAP DAEPAPEAEH
APETLRAPAH RSTPAGPSRL APVIDLQARG AARALAATPP APAAPDLPPA PWEDADDDDV
ANSVAASSSG LMGATLVAKM LGGVVIDEIL DGVSDVRR
//
