ID   A0A2U2BAH7_9BACT        Unreviewed;       683 AA.
AC   A0A2U2BAH7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:PWE00068.1};
GN   ORFNames=DDZ16_06830 {ECO:0000313|EMBL:PWE00068.1};
OS   Marinilabilia rubra.
OC   Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC   Marinilabilia.
OX   NCBI_TaxID=2162893 {ECO:0000313|EMBL:PWE00068.1, ECO:0000313|Proteomes:UP000244956};
RN   [1] {ECO:0000313|EMBL:PWE00068.1, ECO:0000313|Proteomes:UP000244956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WTE16 {ECO:0000313|EMBL:PWE00068.1,
RC   ECO:0000313|Proteomes:UP000244956};
RA   Zhang R.;
RT   "Marinilabilia rubrum sp. nov., isolated from saltern sediment.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWE00068.1}.
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DR   EMBL; QEWP01000004; PWE00068.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U2BAH7; -.
DR   OrthoDB; 9769337at2; -.
DR   Proteomes; UP000244956; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244956}.
FT   DOMAIN          355..534
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   683 AA;  76535 MW;  D54BFCA9A9E677A0 CRC64;
     MKSNVPENYS VKKTDKETLL KWYKLLFLGR TLDERAPNYL KQAIGWSYHA PAAGHDGIQH
     AIGQNFKKEK DHLFPYYRDL QTCISAGMTA EEVIFNGISK DADVAGGGRH MSNHLAKPAW
     NIHNVSSATG NHTLHATGLG RALKTYKEDD AVVISSQGES SVSEGYVYEA INGASNEKLP
     VVFVFQDNGY GISVPKEDQT ANRKVARNFE GFKNLRIIYC NGKDVFDSMN AMEEAVNWAK
     KEQRPVVVHA NCVRIGSHSN SDRHELYRDE NELSYVKEYD PLAKYRRMLL RYERATEDEL
     KDIEEKVTKE VKDAHKKAIK APDPKPESIH DFVLPEPYTS EKYPEGTHND DGEPIKLIQA
     LNETLKSEFR NNPDTYIWGQ DIANKDKGGV FNVSKGMQKE FGKTRVFNAP IAEDYIMGTA
     NGMTRYNDKI RVVVEGAEFA DYFWPAMEQY VEMTHEYWRT KGQFSPNVTV RLASGGYIGG
     GLYHSQTTEG ALSTFPGVRV VYPSFADDAA GLLRTSIRSK GMTLFLEPKA LYNSPKAAAV
     VPDDFEVPFG KARIRRDGKH MTMITYGNTT YMCLEAAEKM SKEDGLEVEV IDLRSLLPLD
     KETIFESLKK TSRALVVHED KVFGGFGGEL SAIIADEAFE LLDAPVKRLG SEFTPVGFNR
     ILEGATLPNT DKILKAAREL AGY
//