ID A0A2U2BCX7_9BACT Unreviewed; 515 AA.
AC A0A2U2BCX7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=DDZ16_00025 {ECO:0000313|EMBL:PWE00918.1};
OS Marinilabilia rubra.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC Marinilabilia.
OX NCBI_TaxID=2162893 {ECO:0000313|EMBL:PWE00918.1, ECO:0000313|Proteomes:UP000244956};
RN [1] {ECO:0000313|EMBL:PWE00918.1, ECO:0000313|Proteomes:UP000244956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WTE16 {ECO:0000313|EMBL:PWE00918.1,
RC ECO:0000313|Proteomes:UP000244956};
RA Zhang R.;
RT "Marinilabilia rubrum sp. nov., isolated from saltern sediment.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWE00918.1}.
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DR EMBL; QEWP01000001; PWE00918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2BCX7; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000244956; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000244956};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..157
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 171..481
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 515 AA; 57155 MW; 08914E5C1D6C5D3F CRC64;
MTSTNQRAEL QQQIWKIAND VRGSVDGWDF KHFVLGTLFY RYISENFTNY IEGGDESVDY
AALDDSVITP EIKEDAIKTK GYFIYPGQLF VNVAKNADNN ENLNTDLAEI FSSIESSANG
FPSEQDIKGL FADFDTTSSR LGGTVENKNS RLAAVLKGVG GLKFGKFEDN QIDLFGDAYE
FLISNYAANA GKSGGEFFTP QNVSKLIAQL AMHKQEKVNK IYDPAAGSGS LLLQAKKHFD
NHIIDEGFFG QEINHTTYNL ARMNMFLHNI NYDKFNIVLG NTLIDPQLWD DKPFDAIVSN
PPYSVKWIGS DDPTLINDDR FAPAGVLAPK SKADFAFVLH ALSYLSGKGR AAIVCFPGIF
YRGGAEQKIR KYLVDNNFVE TVISLPPNLF FGTSIAVNIL VLSKSKNDTT TQFIDASGEE
FYQKATNNNV LTDAHIERIM GMFDSKEDVA HVARQVDNAK VAENEYNLSV SAYVEAKDTR
EVIDIDELNN EIAATVSKID ALRTDIDAIV KEIEA
//
