ID A0A2U2CIC7_9RHOB Unreviewed; 627 AA.
AC A0A2U2CIC7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=C4N9_01085 {ECO:0000313|EMBL:PWE31638.1};
OS Pararhodobacter marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pararhodobacter.
OX NCBI_TaxID=2184063 {ECO:0000313|EMBL:PWE31638.1, ECO:0000313|Proteomes:UP000244940};
RN [1] {ECO:0000313|EMBL:PWE31638.1, ECO:0000313|Proteomes:UP000244940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIC4N-9 {ECO:0000313|EMBL:PWE31638.1,
RC ECO:0000313|Proteomes:UP000244940};
RA Lai Q.Sr., Liu X., Shao Z.;
RT "Pararhodobacter marina sp. nov., isolated from deep-sea water of the
RT Indian Ocean.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWE31638.1}.
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DR EMBL; QEYD01000001; PWE31638.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2CIC7; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000244940; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:PWE31638.1};
KW Hydrolase {ECO:0000313|EMBL:PWE31638.1};
KW Nuclease {ECO:0000313|EMBL:PWE31638.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244940}.
FT DOMAIN 225..343
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 441..584
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 409..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 67275 MW; E4F89C8F782080C6 CRC64;
MYAARPNISQ TLPIIRQLDD SAANRIAAGE VVERPASAVK ELVENALDAG AVRIRVDYSA
GGKTLIRVTD DGHGMTPEDL PLALSRHATS KIDGSDLLNI HTFGFRGEAL PSLGAVGRLK
IASRAEGHDG AEITVNGGAI GPVRPSALNR GTQVELRDLF FATPARLKFL RTDRAESQAI
AEVMRKLAMA EPFVGFTLYD VDGGREILRV DAEQGELFDA LGARLTRLMG RDFTENALRI
ETERDGVRLS GFAALPTFSR GSTVAQHLFV NGRPVRDKLL IGALRAAYMD VLSRDRHPAA
VLFIDCDPHH VDVNVHPAKA EVRFRDSGIV RGLVVSGLRH ALAAAGHRAS GTVATETLGA
FRPESTGGNP APRIYQMDFA SRPSTGALRD SYAAQAPVDP ILDEAPASWQ PAAASGWDSD
GATSARIEPA HGPTDTPLGA ARAQLHENYI IAQTRDGLVI VDQHAAHERL VYERLKAQKD
AHGVKAQALL IPEIVSLSPS DAQRLLDHAE TLATLGLVLE PFGGDAIAVR ETPAALGNCD
ARGLVLDILD ELADLGQSQA LGARIDAVLS RMACHGSIRS GRQMRAEEMN ALLREMEATP
LSGQCNHGRP TYVELKLSDI EKLFGRR
//
