ID A0A2U2HDC7_9BURK Unreviewed; 503 AA.
AC A0A2U2HDC7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Tryptophan 7-halogenase {ECO:0000313|EMBL:PWF40990.1};
GN ORFNames=C7C56_025540 {ECO:0000313|EMBL:PWF40990.1};
OS Massilia glaciei.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1524097 {ECO:0000313|EMBL:PWF40990.1, ECO:0000313|Proteomes:UP000241421};
RN [1] {ECO:0000313|EMBL:PWF40990.1, ECO:0000313|Proteomes:UP000241421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B448-2 {ECO:0000313|EMBL:PWF40990.1,
RC ECO:0000313|Proteomes:UP000241421};
RA Wang H.;
RT "Massilia violaceinigra sp. nov., a novel purple-pigmented bacterium
RT isolated from Tianshan glacier, Xinjiang, China.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWF40990.1}.
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DR EMBL; PXWF02000321; PWF40990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2HDC7; -.
DR OrthoDB; 8868802at2; -.
DR Proteomes; UP000241421; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000241421}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 335
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 344
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 503 AA; 56112 MW; 6509818392614A19 CRC64;
MTLTPVRKIV VVGGGTAGWM TASALSKTLG PACQIRLIES DEIGIIGVGE ATIPHINEFN
RALGIDEDTF LRATQGTFKL GIEFVNWGQT GERYIHGFGR VGQPGDALPF HHFWLRMAKL
GRAGPLAAYS MNTAAPHHAK FMRAPPEMRG SPLQDLVHAF HFDASLYARF LRDYAEQRGV
RRTEGKIARV SQREPDGFID AVVMESGERI EGDFFVDCSG MRALLIEQTL HAGYEDWSHW
LPCDRAIAVP CASAGELLPM TRSTAHAAGW QWRIPLQHRT GNGHVYSSGF MEADQAEAIL
MANLDGEPTA QPRHIRFQTG RRKKSWSHNC VSVGLASGFM EPLESTSIHL IQTAISRIIN
FFPQAGFDAA DIAEYNLQTQ VEYERIRDFL VLHYKVTRRT DSAFWDYCRT MPIPESLQRK
IDLFLSNGRI YREQDELFTE MSWLQVMVGQ GAMPRGYHPF ADLRPEAEVA AYLGNVEQVI
AKCVKAMPSQ AEFIAAHCAA GAN
//
