ID A0A2U2HNA9_9BURK Unreviewed; 1183 AA.
AC A0A2U2HNA9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=C7C56_008945 {ECO:0000313|EMBL:PWF49004.1};
OS Massilia glaciei.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Massilia.
OX NCBI_TaxID=1524097 {ECO:0000313|EMBL:PWF49004.1, ECO:0000313|Proteomes:UP000241421};
RN [1] {ECO:0000313|EMBL:PWF49004.1, ECO:0000313|Proteomes:UP000241421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B448-2 {ECO:0000313|EMBL:PWF49004.1,
RC ECO:0000313|Proteomes:UP000241421};
RA Wang H.;
RT "Massilia violaceinigra sp. nov., a novel purple-pigmented bacterium
RT isolated from Tianshan glacier, Xinjiang, China.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWF49004.1}.
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DR EMBL; PXWF02000121; PWF49004.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2HNA9; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000241421; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Ligase {ECO:0000256|ARBA:ARBA00023146};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000241421};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 25..92
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1183 AA; 130038 MW; C4807DB1BBB64038 CRC64;
MSMDVLERDG AAAPAPAVPN GPAFVHLRVH SEYSIVDGLV RIDDVVAAAA KDKQPALAIT
DLANLFGMVK FYKAARGKGI KPVIGVDAWI SNDDNRDKPS RLLLLAKNRM GYLQLCELLS
NAWLSNQHKG RAEIRPEWLA ALATSESTLN PGESQANGLI VLSGAHFGDV GTAIENGNLA
LAERCAARWA AIFPGHFYIE VQRAGQPNQE AQVRQAAALA AKLGLPVVAT HPIQFLSPEE
FVAHEARTCI AEGEMLANAK RVKRFNESMR FKSQAEMAEL FADMPGALAN SVHIAKRCNV
VLTLGKPQLP NFPTPPGMTI DQFLVSESKA GLEQRLVHLY PDPAKREAQR ARYEDRLKFE
TDTISNMGFP GYFLIVAEFI RWAKENGVPV GPGRGSGAGS LVAYSLLITD LDPLQYNLLF
ERFLNPERVS MPDFDIDFCQ EGRDRVIQHV KDLYGKEAVS QIATFGTMAA KGAIRDVGRV
LDFGYNFCDG ISKLIPFKPG KPVTIADAIA EEPMLAERLE NEDEVKQLLA LAQQVEGIAR
NIGMHAGGVL IAPGKLTDFC PLYTQGGDSG VVSQYDKDDV EAVGLVKFDF LGLTTLTILD
RAVRYIKQLD PANADFALEK LPLNDKASYE LLTKAKTVAV FQLESRGMQG MLKDARPDRF
EDIIALVALY RPGPMDLIPD FCKRKHGEKF DYPDPRTESI LSETYGIMVY QEQVMQMAQI
VGGYSLGGAD MLRRAMGKKK AEEMAEHREI FRAGAAKDGL TAAKADEIFD LMEKFAGYGF
NKSHAAAYAL LSYHTAYLKA HHTAAFMAAN LSLAMDDTDK IKILVEDSLD ICGLTLLPPD
VNHSDYRFTP EGEAPSVSKK RVTNIRYGLG AVKGSGQGAI EAIIAARTAG GHFTDLFDFC
KRVDRKQINR RTIESLIRAG AFDCFKVDRA ILLASVAFAV ECADQAHASI NQVSLFGGDD
SDMVAPPEYV KATPWTDRQK LSEEKIALGF YLSGHMFDSF AVEARRFSRT KLKDLEPSRD
PRMMCGVITG IRTQMTQRGK ILIVSLDDKT AVVEVTVYNE VFDANKSMFK EDEFLLVVGK
VSEDRFNGGL RITAEKVFDL TASRVQYGSH FGMFLPAPVP SSKIAEVLQP HRNPAGLAVL
MRLKPQGVDC TLQFGEEWRV APSDALTLAL ERGLGAREVR VEY
//
