ID A0A2U2IZ71_9SPHN Unreviewed; 353 AA.
AC A0A2U2IZ71;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:PWG01379.1};
GN ORFNames=DF286_14770 {ECO:0000313|EMBL:PWG01379.1};
OS Sphingosinicella humi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingosinicellaceae; Sphingosinicella.
OX NCBI_TaxID=2068657 {ECO:0000313|EMBL:PWG01379.1, ECO:0000313|Proteomes:UP000245916};
RN [1] {ECO:0000313|EMBL:PWG01379.1, ECO:0000313|Proteomes:UP000245916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QZX222 {ECO:0000313|EMBL:PWG01379.1,
RC ECO:0000313|Proteomes:UP000245916};
RA Qiao Z., Wang G.;
RT "Genome of Sphingosinicella humi QZX222.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWG01379.1}.
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DR EMBL; QFFF01000002; PWG01379.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2IZ71; -.
DR OrthoDB; 9806940at2; -.
DR Proteomes; UP000245916; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000245916};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 11..344
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 353 AA; 38100 MW; 2B9E764C2817A8C2 CRC64;
MPAANAYAVH APTDRFQPFS FDRREPNPND VAIAIRYCGV CHSDLHTARS EWGGTRYPCV
PGHEIVGEVT AVGDAVTRFQ PGDIVGVGCM VDSCLSCASC REGLEQYCEV GFTGTYNGPT
QDSGDNSYGG YSDRIVVREE FVLHIRHREE QLAAVAPLLC AGITTWSPLR HWKIGPGKKV
GVVGIGGLGH MGLKLAHALG AHVVAFTTSP DKKQDALALG ADEVVVSRNP DEMNAHAGSF
DFILNTVAAP HDLDAFLTLL KRDGTMAMVG APAEPHPSPA IFNFVLKRRS LAGSLIGGIK
ETQEMLDFCA EHDIVSDIEM IAMQDIDEAY DRMLRGDVKY RFVIDTATIG EAS
//
