ID A0A2U2J6C6_9SPHN Unreviewed; 971 AA.
AC A0A2U2J6C6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Monovalent cation/H+ antiporter subunit A {ECO:0000313|EMBL:PWG03852.1};
GN ORFNames=DF286_05050 {ECO:0000313|EMBL:PWG03852.1};
OS Sphingosinicella humi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingosinicellaceae; Sphingosinicella.
OX NCBI_TaxID=2068657 {ECO:0000313|EMBL:PWG03852.1, ECO:0000313|Proteomes:UP000245916};
RN [1] {ECO:0000313|EMBL:PWG03852.1, ECO:0000313|Proteomes:UP000245916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QZX222 {ECO:0000313|EMBL:PWG03852.1,
RC ECO:0000313|Proteomes:UP000245916};
RA Qiao Z., Wang G.;
RT "Genome of Sphingosinicella humi QZX222.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWG03852.1}.
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DR EMBL; QFFF01000001; PWG03852.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2J6C6; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000245916; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245916};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..114
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 130..408
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 619..682
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 700..795
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 821..943
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 971 AA; 104538 MW; 090E483627156E33 CRC64;
MSNEALLLVI ITFPFLGSLL AAFLPSTARN AAAALAGTIA LVGTLLTALL YSSVADGAVV
RSEIEWLPSL GLNLLIRIDG LSWIFSTLVL GIGALVVLYA RYYMSPADPV PRFFSFLLAF
MGSMLGLVLS GNLVQLAFFW ELTSLFSFLL IGYWHHNRTA RDAARMALIA TAAGGLCLLI
GILVIGMIVG SYDLDQVLAS GDLIRSSDLY VPALILILIG AFTKSAQFPF HFWLPHAMAA
PTPVSAYLHS ATLVKAGVFL LMRLWPALAG TDAWYFIVSS AGLATLLVGA WSAIFQQDLK
GLLAYSTISH LGLITLLLGL GSPLGAVAAI FHAVNHATFK ASLFMAGGII DHEAGTRDLR
RLSGLYRYMP ITATLAMVAA AAMAGVPLLN GFLSKEMFLS ASLEEHSGTV LDQLLPLIAT
LASAFSVLYS FRFIHQTFFG PAPTDLPREP GEAPPWMRVP IEILVLACLL VGMLPSATIG
PFLATAVRSV MGEDMPTYSL AVWHGFNRPL LMSVTALVLG SIGYLAFRDA LNRREGAPLI
RHLKGRKIFE AGLAVVVSAA RGLERLLGTR RLQPQLRLLV LVAFIAGLLP FLRLGYSLGG
MEGTIVDPGF AVIWMIGGAC AIGAAWQAKY HRLAALILTG GAGLVSCISF LWLSAPDLAL
TQLLVETVTT VLLLLGLRWL PKQLPESWPE GRTPFAVRRR RAFDLAIAIA AGIGMTLIAY
AVMTRTLPNS ISRFFVERAY PDAGGTNVVN VILVDFRAFD TLGEITVLAI VGLTVFSLLR
RFRPAPESLG VPEQQLHQDA LDEAREGRNV GDTLANYLLV PSVIMEWLFP VILVFAIYLW
IRGHDMPGGG FAAGIALSIA LIVQYMAAGT RRVEARLRVQ PARWIGYGML LAALTGAGAW
LFDRPFLTSH FSYLDIPLLG RMPVASALLF DLAVFLLVVG ATALVLIALA HQSIRRPFVP
PVRPAPLEGE G
//
