ID A0A2U2J991_9FLAO Unreviewed; 783 AA.
AC A0A2U2J991;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=DIS07_10450 {ECO:0000313|EMBL:PWG04882.1};
OS Polaribacter aquimarinus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=2100726 {ECO:0000313|EMBL:PWG04882.1, ECO:0000313|Proteomes:UP000245670};
RN [1] {ECO:0000313|EMBL:PWG04882.1, ECO:0000313|Proteomes:UP000245670}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZY113 {ECO:0000313|EMBL:PWG04882.1,
RC ECO:0000313|Proteomes:UP000245670};
RA Lu D.;
RT "Polaribacter aquimarinus sp. nov., isolated from sediment in a sediment of
RT sea.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWG04882.1}.
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DR EMBL; QFFG01000004; PWG04882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2J991; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000245670; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PWG04882.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245670};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 591..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 89186 MW; 5F8D0F7A54977D61 CRC64;
MKVCIAEKPS VAREIANILG AKTKRDGFYE GNGYAVTYTF GHLCTLLEPK DYKPHWKSWD
LNNLPMLPER FDTKVTGDSG IKKQFNIVKG LFEKADVVIN CGDAGTEGEL IQRWVINQCN
YKGKVQRLWI SSLTEEAIKD GFNNLKSSEK YDNLYYAGYS RAIGDWLLGL NATRLYTVKF
GGYKQVLSVG RVQTPTLAML VNRYFEIQNF KPQPYWELQT TYRNTLFNYE DGRFLKKEDG
QILADKVAQS EFEIVSVTKK KGKEYAPKLF DLTGLQVYCN NKFGFSADET LKMVQKLYEM
KVVTYPRVDT TFLPNDLYPK VHGILSKLTN YSELTQPLLG KKIKKTKRVF DDKKVTDHHA
IIPTGIQGNL QYNQQQVYDI ITKRFIAVFY PDSDVSNTSV IGKAAEVPFK TTGKEIINKG
WRVVFETEES KVKKELNAQA TLPSFAKGEK GKHEPSFLEK ETKPPRNYTE ASLLRAMETA
GKQVDDDEMR ELMKENGIGR PSTRASIIET LFRRKYIERK KKLVLPTQTG IDLINIIDNE
LLKSAELTGR WEKRLKEIER GEFNAGTFIN NMKKMVDELV YEVRSNKNKK RISSNNDVSS
SAVENSTKSK TKKTKKSKTV AGKTCPKCKT GKLLKGSTAF GCSEYKNNCK FKIPFQFLEK
KISENQIIRL IDKGCTTNLK GFKIDGKSAQ GLVRFDDDFE LKFEPKLKVT SSTVQKSPQN
RNDNTEKITC PECKKGTILK GKLAYGCSEY KTGCDFVFTF ENIKKIANGK TLTKELVLEI
IRS
//
