ID A0A2U2N202_9GAMM Unreviewed; 1158 AA.
AC A0A2U2N202;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=DEM34_09060 {ECO:0000313|EMBL:PWG63216.1};
OS Spiribacter halobius.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Spiribacter.
OX NCBI_TaxID=2182432 {ECO:0000313|EMBL:PWG63216.1, ECO:0000313|Proteomes:UP000245474};
RN [1] {ECO:0000313|EMBL:PWG63216.1, ECO:0000313|Proteomes:UP000245474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E85 {ECO:0000313|EMBL:PWG63216.1,
RC ECO:0000313|Proteomes:UP000245474};
RA Zheng W.-S., Lu D.-C., Du Z.-J.;
RT "Spiribacter halobius sp. nov., a moderately halophilic bacterium isolated
RT from marine solar saltern.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWG63216.1}.
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DR EMBL; QFFI01000012; PWG63216.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2N202; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000245474; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000245474}.
FT DOMAIN 625..786
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 799..966
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 129672 MW; A911EE72CC3875AC CRC64;
MADQSASPLR PPIPRSPGER RDWYGLPEPA QALALASAAE AHTGLVLAVA ASSQQALHLE
AELGFFLDGR LPVEVMPDWE TLPYDVFSPH QDIISQRLRT LHDLPGLTRG VLIVPAGTLM
QRIAPRSFLE GTVLRVAVGD HLALEPMRER LERAGYRCVS EVMEHGEFAV RGSLLDLYPM
GSETPYRIDL FDDEVDSIRL FDPETQRSAQ KVDRIELLPA REFPTGEEGI TRFRRQYRAA
FEGDPTASTV YRDVSDGRMP NGIEYYLPLF FEQTGTLFDY LPEGALAVRT GPVDEQLGAD
WEQIAERYEQ RRHDRERPLL PPERLYLSPD EVRSALNRLP QVRIPAEDAE PTGQAREVTF
TTSTLPDLRS EPGAARPLGR LEAFAAEAPE RLLFLAETAG RRETLRERLQ QAGLRPEDVS
GWAAFAAGDP ALGLTVGPLE AGFRLPDDGI AVVPDTALFA ERAKQRRRRQ STAERDPDAI
IRDLTDLHPG APVVHENHGV GRYRGLQTLD VGNVRTEFLT LEYAGGDKLY VPVASLHLIT
RYTGTDSDAA PLHRLGGEQW EKARRKAAER ARDVAAELLD IYARREAQSG HAHRFPREEY
ERFAAQFPFE ETPDQETAIH AVIRDLEQER PMDRVVCGDV GFGKTEVAMR AAFVGVQAGG
QVAVLVPTTL LAQQHYQNFS DRFADWPVRI ELLSRFRSQK EQNAVLRDLA AGKVDIVIGT
HKLLQGSVKF DNLGLLIIDE EHRFGVRQKE ALKRLRANVD VLTLTATPIP RTLNMSLAGM
RDLSIIATPP ARRLAVKTFV NQWNDALIRE ACLRELHRGG QVYFLHNDVE TIERVARELE
ALVPEARVRI AHGQMREREL ERVMLDFYHQ RFNVLVCTTI VESGIDVPSA NTIVINRADR
LGLAQLHQLR GRVGRSHHRA YAYLVAPPKR QLTPDAAKRL EAIASLEDLG IGFALASHDL
EIRGAGELLG EGQSGQIQEV GFSMYSELLE RAVRDLRAGR EPALDRPLHH GTEVDLRIPA
LLPEEYLPDV HTRLVLYKRI ASAPDENALR ELQVEMIDRF GLLPEPARNL FRLAELRLRA
ERLGLERIEA GPGGGVLTFS DTPRVDPAAL VQLVQEKPAV YRLEGQERLR FRLETEAADE
RIGVVSQLMD ALEQKEAA
//