ID A0A2U2N8Y0_9GAMM Unreviewed; 837 AA.
AC A0A2U2N8Y0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DUF3772 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DEM34_01330 {ECO:0000313|EMBL:PWG65414.1};
OS Spiribacter halobius.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Spiribacter.
OX NCBI_TaxID=2182432 {ECO:0000313|EMBL:PWG65414.1, ECO:0000313|Proteomes:UP000245474};
RN [1] {ECO:0000313|EMBL:PWG65414.1, ECO:0000313|Proteomes:UP000245474}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E85 {ECO:0000313|EMBL:PWG65414.1,
RC ECO:0000313|Proteomes:UP000245474};
RA Zheng W.-S., Lu D.-C., Du Z.-J.;
RT "Spiribacter halobius sp. nov., a moderately halophilic bacterium isolated
RT from marine solar saltern.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PWG65414.1}.
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DR EMBL; QFFI01000002; PWG65414.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2U2N8Y0; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000245474; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245474};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..837
FT /note="DUF3772 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015674776"
FT TRANSMEM 208..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 637..704
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 713..793
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 398..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 89915 MW; BB3C2535CA38D513 CRC64;
MRAQQFPFFP LRLLLLLTAL ALTVAAPAQE AERPDLETRI AEWEAVNERA STALANDFRG
RDLESVKGDL REMISAAAAA RRSAEARLAA AEQQLESLGE PPGEDAPPEN ARIAELRAQM
QRDASRHEAM ATEARLVEEN GEKLLQEIAA WERARFRAAI LERKPAPVWP SVWLAAGRDG
VALAAEVISA PLRWWQARVE AGTSWQQLAL VGGVALGGLL LAWPLRLWLL RRYGRDPEDT
DPSYARRLIA ALADGLANAV LPVVVLAAVL LVLAWQGLMT GLFGLMAYTV GGAVAGFVLV
LGVARAALSP HRIAWRILPV RPEHIGALLT AIRLLTAVMA VSLTVLVTAF FSGHMTDALE
ATVFLASTTA VAILAGWILS PRFWTVSVEA SQEASAEGAE TDATAAASEP PADAREARSW
PDRIRGLVRL VVMAAPLLAL AGFGRLAFFV QSRLLGLGLI AALAVLLRLA AREMLERFFM
RRRRQFGLSG DTTEGGVRIA VFWAGFVLDL LLLLPIAYAV MLLFGVPLTT ITLWTTQLLT
GISIGNFTLS LADLIAAITV LVTGLFLTNL FRRWLSNRVL PHTRLDIGAR NSVAAGAGYL
GVGLALVLAV ATLGVDFSNL AIVAGALSVG IGFGLQNVVQ NFAAGLLLLI ERPIKVGDWI
IVGGNEGTVK HISVRSTEIE TFDRSSVIVP NSDLISLPVT NWTHKNRIAR VIVPVRVAYG
SDTAAVAETL HRCARENRDV LRHPAPTALF LGFGDSCLNF ELRCFIGDTD RYLDVRSDLH
FAVDQAFREA GIVMPFPQRD VHLQGGQDHG PPPGTTSAPS RPAGASGGGP ESGDAPE
//
