ID   A0A2U2YWZ7_9ACTN        Unreviewed;       501 AA.
AC   A0A2U2YWZ7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=S-adenosyl-L-homocysteine hydrolase NAD binding domain-containing protein {ECO:0000259|SMART:SM00997};
GN   ORFNames=DIZ27_44715 {ECO:0000313|EMBL:PWI04546.1};
OS   Streptomyces sp. NWU339.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2185284 {ECO:0000313|EMBL:PWI04546.1, ECO:0000313|Proteomes:UP000245372};
RN   [1] {ECO:0000313|EMBL:PWI04546.1, ECO:0000313|Proteomes:UP000245372}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NWU339 {ECO:0000313|EMBL:PWI04546.1,
RC   ECO:0000313|Proteomes:UP000245372};
RA   Adegboye M.F., Lobb B., Babalola O., Doxey A.C., Ma K.;
RT   "Draft genomes of two novel cellulolytic Streptomyces strains isolated from
RT   South African rhizosphere soils.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC       {ECO:0000256|ARBA:ARBA00007122}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PWI04546.1}.
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DR   EMBL; QFRK01000154; PWI04546.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2U2YWZ7; -.
DR   OrthoDB; 3207107at2; -.
DR   Proteomes; UP000245372; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR   InterPro; IPR000043; Adenosylhomocysteinase-like.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR   PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SMART; SM00997; AdoHcyase_NAD; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245372}.
FT   DOMAIN          275..439
FT                   /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT                   /evidence="ECO:0000259|SMART:SM00997"
SQ   SEQUENCE   501 AA;  54057 MW;  0F2D853FBBB5C868 CRC64;
     MPASVKPPLV HAVDVVATQD EARHLASELA ARLALSPGVQ SMDWDEASAS WRCALADGGR
     GRLTLAAPAD PAAAAAHTHR IVATFEQGPP AAAEAFFTAA RHLPFTATEV TAAVSELPLT
     SRLADRWSDK PLSGVGVLWT IHHMRDFLVL VDSLLGLGVD PGHMTVIDKE YPYAHTHRVD
     AHLVQRHGIA VWRYRDLRQG IEDHIERVAA AGKRTVVMDD GGYVMPTVLR ELPGQADHFV
     GLVEQTTSGI RKVEGLDLPL PLFSVAESDM KSMIESYGIA DAAVRNTLRL LPDEKLEGQA
     ALVLGFGRIG HEVARVLENR RMRVAVFDSD ITRLVAAHEE GFLTSRSLEQ LVRTHQPRLV
     IGCVGSRSFG AREARLLPER SYLVSTTSRN FEFDLDELRA GSTAVTDRGV LGTGYKLAGG
     PEIVVLGHGM PINFHYAESL SNRYVDLVLA GLAVGAVAMA RADERLQPGH NVAATNTILA
     EAGIVDDYYR LYGPAAGGGR G
//